{"id":8666,"date":"2023-06-29T01:44:37","date_gmt":"2023-06-29T01:44:37","guid":{"rendered":"https:\/\/vospan.com\/?post_type=product&#038;p=8666"},"modified":"2024-03-13T08:20:18","modified_gmt":"2024-03-13T08:20:18","slug":"timstof-scp-2","status":"publish","type":"product","link":"https:\/\/vospan.com\/san-pham\/timstof-scp-2\/","title":{"rendered":"timsTOF SCP"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_67_1 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<label class=\"ez-toc-title ez-toc-toggle\" style=\"cursor: pointer\">T&oacute;m t\u1eaft n\u1ed9i dung<\/label>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #0a0a0a;color:#0a0a0a\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #0a0a0a;color:#0a0a0a\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/vospan.com\/san-pham\/timstof-scp-2\/#Dinh_nghia_lai_proteomics_don_bao\" title=\"\u0110\u1ecbnh ngh\u0129a l\u1ea1i proteomics \u0111\u01a1n b\u00e0o\">\u0110\u1ecbnh ngh\u0129a l\u1ea1i proteomics \u0111\u01a1n b\u00e0o<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/vospan.com\/san-pham\/timstof-scp-2\/#Chuyen_ion_duoc_cai_thien_triet_de\" title=\"Chuy\u1ec3n ion \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n tri\u1ec7t \u0111\u1ec3\">Chuy\u1ec3n ion \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n tri\u1ec7t \u0111\u1ec3<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/vospan.com\/san-pham\/timstof-scp-2\/#Nhung_cai_tien_dang_ke_ve_hieu_suat_proteomics\" title=\"Nh\u1eefng c\u1ea3i ti\u1ebfn \u0111\u00e1ng k\u1ec3 v\u1ec1 hi\u1ec7u su\u1ea5t proteomics\">Nh\u1eefng c\u1ea3i ti\u1ebfn \u0111\u00e1ng k\u1ec3 v\u1ec1 hi\u1ec7u su\u1ea5t proteomics<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/vospan.com\/san-pham\/timstof-scp-2\/#Dual-TIMS_phan_tich_ho_tro_CCS\" title=\"Dual-TIMS, ph\u00e2n t\u00edch h\u1ed7 tr\u1ee3 CCS\">Dual-TIMS, ph\u00e2n t\u00edch h\u1ed7 tr\u1ee3 CCS<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/vospan.com\/san-pham\/timstof-scp-2\/#Ly_tuong_cho_mien_dich_va_cac_quy_trinh_khac\" title=\"L\u00fd t\u01b0\u1edfng cho mi\u1ec5n d\u1ecbch v\u00e0 c\u00e1c quy tr\u00ecnh kh\u00e1c\">L\u00fd t\u01b0\u1edfng cho mi\u1ec5n d\u1ecbch v\u00e0 c\u00e1c quy tr\u00ecnh kh\u00e1c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/vospan.com\/san-pham\/timstof-scp-2\/#PASEF%C2%AE\" title=\"PASEF\u00ae\">PASEF\u00ae<\/a><\/li><\/ul><\/nav><\/div>\n<h3 class=\"ui-typography--h2\"><span class=\"ez-toc-section\" id=\"Dinh_nghia_lai_proteomics_don_bao\"><\/span><strong>\u0110\u1ecbnh ngh\u0129a l\u1ea1i proteomics \u0111\u01a1n b\u00e0o<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p class=\"ui-typography--h2\"><strong>Quang h\u1ecdc ion ti\u00ean ti\u1ebfn v\u00e0 PASEF \u0111\u1ec3 nghi\u00ean c\u1ee9u t\u00ednh kh\u00f4ng \u0111\u1ed3ng nh\u1ea5t c\u1ee7a t\u1ebf b\u00e0o v\u00e0 sinh h\u1ecdc t\u1eeb m\u1ed9t t\u1ebf b\u00e0o \u0111\u01a1n l\u1ebb<\/strong><br \/>\nProtein kh\u1ed1i ph\u1ed5 \u0111\u00e3 tr\u1edf th\u00e0nh m\u1ed9t y\u1ebfu t\u1ed1 ch\u00ednh c\u1ee7a nghi\u00ean c\u1ee9u hi\u1ec7n \u0111\u1ea1i nh\u1eb1m t\u00ecm hi\u1ec3u ch\u1ee9c n\u0103ng sinh h\u1ecdc v\u00e0 c\u01a1 ch\u1ebf b\u1ec7nh t\u1eadt.\u00a0C\u00e1c m\u00f4 kh\u1ecfe m\u1ea1nh ho\u1eb7c b\u1ecb b\u1ec7nh c\u00f3 v\u1ebb \u0111\u1ed3ng nh\u1ea5t bao g\u1ed3m c\u00e1c t\u1ebf b\u00e0o v\u1edbi nhi\u1ec1u lo\u1ea1i protein kh\u00e1c nhau.\u00a0Th\u00e1ch th\u1ee9c gi\u1ea3i m\u00e3 c\u00e1c proteome trong m\u1ed7i t\u1ebf b\u00e0o \u0111\u01a1n l\u1ebb &#8211; t\u00ednh kh\u00f4ng \u0111\u1ed3ng nh\u1ea5t c\u1ee7a t\u1ebf b\u00e0o &#8211; n\u1eafm gi\u1eef ch\u00eca kh\u00f3a \u0111\u1ec3 hi\u1ec3u \u0111\u1ea7y \u0111\u1ee7 ch\u1ee9c n\u0103ng c\u1ee7a n\u00f3.<br \/>\nTimsTOF SCP \u0111\u01b0a ra kh\u00e1i ni\u1ec7m ngu\u1ed3n ion \u0111\u01b0\u1ee3c c\u1ea3i ti\u1ebfn tri\u1ec7t \u0111\u1ec3.\u00a0K\u1ebft h\u1ee3p v\u1edbi ph\u00e2n m\u1ea3nh n\u1ed1i ti\u1ebfp t\u00edch l\u0169y song song (PASEF\u00a0<sup>\u00ae<\/sup>), n\u00f3 cung c\u1ea5p t\u1ed1c \u0111\u1ed9 v\u00e0 \u0111\u1ed9 nh\u1ea1y c\u1ef1c cao \u0111\u1ec3 x\u1eed l\u00fd c\u00e1c h\u1ec7 protein c\u1ee7a c\u00e1c t\u1ebf b\u00e0o \u0111\u01a1n l\u1ebb ho\u1eb7c \u0111\u0103ng c\u00e1c s\u1eeda \u0111\u1ed5i t\u1ecbnh ti\u1ebfn trong m\u1ed9t v\u00e0i t\u1ebf b\u00e0o t\u01b0\u01a1ng t\u1ef1 v\u1ec1 m\u1eb7t h\u00ecnh th\u00e1i ho\u1eb7c ch\u1ee9c n\u0103ng.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/www.bruker.com\/en\/products-and-solutions\/mass-spectrometry\/timstof\/timstof-scp\/_jcr_content\/root\/sections\/features\/sectionpar\/twocolumns\/contentpar-2\/image.coreimg.82.1920.jpeg\/1622474197905\/timstof-truescp-cell.jpeg\" width=\"566\" height=\"246\" \/><\/p>\n<h3 class=\"ui-typography--h2\"><span class=\"ez-toc-section\" id=\"Chuyen_ion_duoc_cai_thien_triet_de\"><\/span><strong>Chuy\u1ec3n ion \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n tri\u1ec7t \u0111\u1ec3<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/www.bruker.com\/en\/products-and-solutions\/mass-spectrometry\/timstof\/timstof-scp\/_jcr_content\/root\/sections\/features\/sectionpar\/twocolumns_893226279\/contentpar-1\/image.coreimg.82.1920.jpeg\/1623149258148\/timstof-scp-technology.jpeg\" width=\"506\" height=\"313\" \/><\/p>\n<p>TimsTOF SCP c\u00f3 d\u1ea1ng h\u00ecnh h\u1ecdc ngu\u1ed3n ion \u0111\u01b0\u1ee3c s\u1eeda \u0111\u1ed5i bao g\u1ed3m nh\u1eadn d\u1ea1ng mao d\u1eabn 1 mm \u0111\u1ec3 truy\u1ec1n ion cao h\u01a1n n\u0103m l\u1ea7n v\u00e0o m\u1ed9t ph\u1ec5u ion giai \u0111o\u1ea1n \u00e1p su\u1ea5t cao h\u01a1n b\u1ed5 sung v\u00e0 h\u1ec7 th\u1ed1ng ch\u00e2n kh\u00f4ng \u0111\u01b0\u1ee3c b\u01a1m kh\u00e1c bi\u1ec7t 8 giai \u0111o\u1ea1n.<\/p>\n<p>Mao qu\u1ea3n l\u1edbn h\u01a1n mang l\u1ea1i \u0111\u1ed9 nh\u1ea1y c\u1ef1c cao v\u00e0 ph\u1ea3n x\u1ea1 ion tr\u1ef1c giao b\u1ed5 sung v\u00e0 ph\u1ec5u ti\u1ebfp theo cung c\u1ea5p m\u1ed9t giai \u0111o\u1ea1n \u0111\u01b0\u1ee3c b\u01a1m kh\u00e1c bi\u1ec7t, ri\u00eang bi\u1ec7t, duy tr\u00ec \u0111\u1ed9 b\u1ec1n c\u1ee7a h\u1ec7 th\u1ed1ng nh\u01b0 mong \u0111\u1ee3i t\u1eeb lo\u1ea1t thi\u1ebft b\u1ecb timsTOF.<\/p>\n<div class=\"aem-headline\">\n<h3 class=\"ui-typography--h2\"><span class=\"ez-toc-section\" id=\"Nhung_cai_tien_dang_ke_ve_hieu_suat_proteomics\"><\/span><strong>Nh\u1eefng c\u1ea3i ti\u1ebfn \u0111\u00e1ng k\u1ec3 v\u1ec1 hi\u1ec7u su\u1ea5t proteomics<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<\/div>\n<div class=\"aem-Grid aem-Grid--12 aem-Grid--default--12 aem-Grid--phone--12 ui-styles__background-item\">\n<div class=\"responsivegrid aem-GridColumn--default--none aem-GridColumn--phone--none aem-GridColumn--phone--12 aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--phone--0 aem-GridColumn--offset--default--0\">\n<div class=\"aem-Grid aem-Grid--6 aem-Grid--default--6 aem-Grid--phone--12 \">\n<div class=\"ui-typography--richtext aem-GridColumn--phone--12 aem-GridColumn aem-GridColumn--default--6\">\n<div class=\"aem-text\">\n<div class=\"ui-typography--richtext\">\n<p>TimsTOF SCP cung c\u1ea5p c\u00e1c c\u1ea3i ti\u1ebfn trong vi\u1ec7c truy\u1ec1n ion v\u00e0o ngu\u1ed3n trong khi v\u1eabn duy tr\u00ec \u0111\u1ed9 b\u1ec1n v\u1edbi t\u1ea7ng ch\u00e2n kh\u00f4ng \u00e1p su\u1ea5t cao h\u01a1n \u0111\u01b0\u1ee3c b\u1ed5 sung.\u00a0\u0110i\u1ec1u n\u00e0y d\u1eabn \u0111\u1ebfn c\u1ea3i thi\u1ec7n g\u1ea7n 5 l\u1ea7n d\u00f2ng ion.\u00a0Khi k\u1ebft h\u1ee3p v\u1edbi ph\u01b0\u01a1ng ph\u00e1p Evosep One Whisper ch\u1ea1y \u1edf t\u1ed1c \u0111\u1ed9 d\u00f2ng ch\u1ea3y 100 nL\/ph\u00fat v\u00e0 \u0111\u01b0\u1eddng k\u00ednh<strong><br \/>\n<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"responsivegrid aem-GridColumn--default--none aem-GridColumn--phone--none aem-GridColumn--phone--12 aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--phone--0 aem-GridColumn--offset--default--0\">\n<div class=\"aem-Grid aem-Grid--6 aem-Grid--default--6 aem-Grid--phone--12 \">\n<div class=\"ui-typography--richtext aem-GridColumn--phone--12 aem-GridColumn aem-GridColumn--default--6\">\n<div class=\"aem-text\">\n<div class=\"ui-typography--richtext\">\n<p>Ph\u01b0\u01a1ng ph\u00e1p PASEF, \u0111\u1ea1t \u0111\u01b0\u1ee3c m\u1ee9c t\u0103ng \u0111\u1ed9 nh\u1ea1y kho\u1ea3ng 100 l\u1ea7n so v\u1edbi c\u00e1c k\u1ebft qu\u1ea3 l\u01b0u l\u01b0\u1ee3ng cao tr\u01b0\u1edbc \u0111\u00f3 v\u1edbi Evosep One.\u00a0\u0110i\u1ec1u n\u00e0y cho ph\u00e9p proteomics kh\u00f4ng thi\u00ean v\u1ecb \u1edf c\u1ea5p \u0111\u1ed9 t\u1ebf b\u00e0o \u0111\u01a1n th\u1ef1c s\u1ef1 v\u1edbi kh\u1ea3 n\u0103ng t\u00e1i t\u1ea1o t\u1ed1t, m\u1ea1nh m\u1ebd v\u00e0 l\u1ea7n \u0111\u1ea7u ti\u00ean bao ph\u1ee7 kho\u1ea3ng 1500 protein tr\u00ean m\u1ed7i t\u1ebf b\u00e0o.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<h3 class=\"ui-typography--h2\"><span class=\"ez-toc-section\" id=\"Dual-TIMS_phan_tich_ho_tro_CCS\"><\/span><strong>Dual-TIMS, ph\u00e2n t\u00edch h\u1ed7 tr\u1ee3 CCS<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<div class=\"responsivegrid aem-GridColumn--default--none aem-GridColumn--phone--none aem-GridColumn--phone--12 aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--phone--0 aem-GridColumn--offset--default--0\">\n<div class=\"aem-Grid aem-Grid--6 aem-Grid--default--6 aem-Grid--phone--12 \">\n<div class=\"ui-typography--richtext aem-GridColumn--phone--12 aem-GridColumn aem-GridColumn--default--6\">\n<div class=\"aem-text\">\n<div class=\"ui-typography--richtext\">\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/www.bruker.com\/en\/products-and-solutions\/mass-spectrometry\/timstof\/timstof-scp\/_jcr_content\/root\/sections\/features\/sectionpar\/twocolumns_279542568\/contentpar-2\/image.coreimg.82.1280.jpeg\/1622130541882\/timstof-noise-reduction.jpeg\" width=\"655\" height=\"262\" \/><\/p>\n<div class=\"aem-headline\">\n<p class=\"ui-typography--h2\">Ph\u00e9p \u0111o ph\u1ed5 di \u0111\u1ed9ng ion b\u1ecb b\u1eaby (TIMS) tr\u01b0\u1edbc h\u1ebft l\u00e0 m\u1ed9t k\u1ef9 thu\u1eadt t\u00e1ch trong pha kh\u00ed.\u00a0\u0110i\u1ec1u n\u00e0y gi\u1ea3i quy\u1ebft \u0111\u1ed9 ph\u1ee9c t\u1ea1p c\u1ee7a m\u1eabu th\u00f4ng qua m\u1ed9t chi\u1ec1u ph\u00e2n t\u00e1ch b\u1ed5 sung b\u00ean c\u1ea1nh s\u1eafc k\u00fd l\u1ecfng hi\u1ec7u n\u0103ng cao (HPLC) v\u00e0 ph\u00e9p \u0111o kh\u1ed1i ph\u1ed5, t\u0103ng c\u00f4ng su\u1ea5t c\u1ef1c \u0111\u1ea1i v\u00e0 \u0111\u1ed9 tin c\u1eady trong \u0111\u1eb7c t\u00ednh c\u1ee7a h\u1ee3p ch\u1ea5t.<\/p>\n<p class=\"ui-typography--h2\">Quan tr\u1ecdng kh\u00f4ng k\u00e9m, thi\u1ebft b\u1ecb TIMS c\u0169ng t\u00edch l\u0169y v\u00e0 t\u1eadp trung c\u00e1c ion c\u00f3 kh\u1ed1i l\u01b0\u1ee3ng v\u00e0 t\u00ednh di \u0111\u1ed9ng nh\u1ea5t \u0111\u1ecbnh, cho ph\u00e9p t\u0103ng \u0111\u1ed9 nh\u1ea1y v\u00e0 t\u1ed1c \u0111\u1ed9 \u0111\u1ed9c \u0111\u00e1o.<br \/>\nC\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c chu k\u1ef3 l\u00e0m vi\u1ec7c g\u1ea7n 100% nh\u1edd c\u00f4ng ngh\u1ec7 TIMS k\u00e9p t\u1ea1o \u0111i\u1ec1u ki\u1ec7n t\u00edch t\u1ee5 \u1edf ph\u1ea7n ph\u00eda tr\u01b0\u1edbc, trong khi c\u00e1c ion \u1edf ph\u1ea7n ph\u00eda sau \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng tu\u1ea7n t\u1ef1 t\u00f9y thu\u1ed9c v\u00e0o t\u00ednh di \u0111\u1ed9ng c\u1ee7a ch\u00fang.\u00a0Qu\u00e1 tr\u00ecnh ph\u00e2n m\u1ea3nh n\u1ed1i ti\u1ebfp t\u00edch l\u0169y song song n\u00e0y (PASEF\u00a0<sup>\u00ae<\/sup>) cho ph\u00e9p ph\u00e2n t\u00edch m\u1eb7t c\u1eaft va ch\u1ea1m (CCS).<\/p>\n<p class=\"ui-typography--h2\">Ph\u00e2n t\u00edch h\u1ed7 tr\u1ee3 CCS m\u1edf ra nhi\u1ec1u kh\u1ea3 n\u0103ng ph\u00e2n t\u00edch h\u01a1n n\u1eefa, t\u1eeb nh\u1eadn d\u1ea1ng h\u1ee3p ch\u1ea5t ch\u1eafc ch\u1eafn h\u01a1n \u0111\u1ebfn so kh\u1edbp th\u01b0 vi\u1ec7n \u0111\u00e1ng tin c\u1eady v\u00e0 t\u1ef7 l\u1ec7 ph\u00e1t hi\u1ec7n sai (FDR) th\u1ea5p h\u01a1n trong c\u00e1c b\u1ed9 d\u1eef li\u1ec7u l\u1edbn.<\/p>\n<\/div>\n<div class=\"aem-headline\">\n<div class=\"aem-headline\">\n<h3 class=\"ui-typography--h2\"><span class=\"ez-toc-section\" id=\"Ly_tuong_cho_mien_dich_va_cac_quy_trinh_khac\"><\/span><strong>L\u00fd t\u01b0\u1edfng cho mi\u1ec5n d\u1ecbch v\u00e0 c\u00e1c quy tr\u00ecnh kh\u00e1c<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<\/div>\n<div class=\"aem-Grid aem-Grid--12 aem-Grid--default--12 aem-Grid--phone--12 ui-styles__background-item\">\n<div class=\"responsivegrid aem-GridColumn--default--none aem-GridColumn--phone--none aem-GridColumn--phone--12 aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--phone--0 aem-GridColumn--offset--default--0\">\n<div class=\"aem-Grid aem-Grid--6 aem-Grid--default--6 aem-Grid--phone--12 \">\n<div class=\"ui-typography--richtext aem-GridColumn--phone--12 aem-GridColumn aem-GridColumn--default--6\">\n<div class=\"aem-text\">\n<div class=\"ui-typography--richtext\">\n<p>B\u00ean c\u1ea1nh c\u00e1c \u1ee9ng d\u1ee5ng proteomics t\u1ebf b\u00e0o \u0111\u01a1n th\u1ef1c s\u1ef1 kh\u00f4ng thi\u00ean v\u1ecb, timsTOF SCP c\u0169ng mang l\u1ea1i \u0111\u1ed9 nh\u1ea1y v\u01b0\u1ee3t tr\u1ed9i cho c\u00e1c quy tr\u00ecnh c\u00f4ng vi\u1ec7c li\u00ean quan \u0111\u1ebfn vi\u1ec7c l\u00e0m gi\u00e0u peptide t\u1eeb h\u1ec7 protein.\u00a0C\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 mi\u1ec5n d\u1ecbch h\u1ecdc b\u1eaft \u0111\u1ea7u b\u1eb1ng vi\u1ec7c tinh ch\u1ebf c\u00e1c immunopeptide t\u1eeb huy\u1ebft t\u01b0\u01a1ng ho\u1eb7c m\u00f4.<\/p>\n<p>V\u00ec c\u00e1c immunopeptide hi\u1ec7n di\u1ec7n v\u1edbi s\u1ed1 l\u01b0\u1ee3ng t\u01b0\u01a1ng \u0111\u1ed1i th\u1ea5p trong c\u00e1c m\u1eabu n\u00e0y, n\u00ean timsTOF SCP l\u00e0 l\u00fd t\u01b0\u1edfng cho c\u00e1c thu\u1ed1c mi\u1ec5n d\u1ecbch \u0111\u1ec3 ph\u00e1t hi\u1ec7n kh\u00e1ng nguy\u00ean m\u1edbi trong \u0111\u00f3 v\u1eadt li\u1ec7u c\u00f3 s\u1eb5n b\u1ecb h\u1ea1n ch\u1ebf, ch\u1eb3ng h\u1ea1n nh\u01b0 trong sinh thi\u1ebft b\u1eb1ng kim.\u00a0TimsTOF SCP c\u0169ng c\u00f3 \u0111\u1ed9 nh\u1ea1y \u0111\u1ec3 c\u00e1ch m\u1ea1ng h\u00f3a vi\u1ec7c s\u1eed d\u1ee5ng phosphoproteomics \u0111\u1ec3 nghi\u00ean c\u1ee9u c\u00e1c con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u trong b\u1ec7nh ung th\u01b0.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"aem-Grid aem-Grid--12 aem-Grid--default--12 aem-Grid--phone--12 ui-styles__background-item\">\n<div class=\"responsivegrid aem-GridColumn--default--none aem-GridColumn--phone--none aem-GridColumn--phone--12 aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--phone--0 aem-GridColumn--offset--default--0\">\n<div class=\"aem-Grid aem-Grid--6 aem-Grid--default--6 aem-Grid--phone--12 \">\n<div class=\"ui-typography--richtext aem-GridColumn--phone--12 aem-GridColumn aem-GridColumn--default--6\">\n<div class=\"aem-text\">\n<h3 class=\"ui-typography--richtext\"><span class=\"ez-toc-section\" id=\"PASEF%C2%AE\"><\/span><strong>PASEF<sup>\u00ae<\/sup><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<\/div>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/www.bruker.com\/en\/products-and-solutions\/mass-spectrometry\/timstof\/timstof-scp\/_jcr_content\/root\/sections\/features\/sectionpar\/twocolumns_2089345078\/contentpar-2\/image.coreimg.82.1280.jpeg\/1622132609591\/timstof-pasef-circle.jpeg\" width=\"444\" height=\"284\" \/><\/p>\n<p>C\u00e1c ion peptit \u0111\u01b0\u1ee3c ph\u00e2n t\u00e1ch b\u1eb1ng ph\u00e9p \u0111o ph\u1ed5 di \u0111\u1ed9ng ion b\u1ecb b\u1eaby (TIMS), r\u1eeda gi\u1ea3i (~ 100 ms) v\u00e0 \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n trong th\u1eddi gian bay t\u1ee9 c\u1ef1c (QTOF), t\u1ea1o b\u1ea3n \u0111\u1ed3 nhi\u1ec7t TIMS MS.\u00a0Trong ph\u01b0\u01a1ng ph\u00e1p PASEF\u00a0<sup>\u00ae<\/sup>\u00a0, qu\u00e1 tr\u00ecnh ph\u00e2n t\u00e1ch TIMS t\u01b0\u01a1ng t\u1ef1 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng v\u1edbi t\u1ee9 c\u1ef1c ph\u00e2n l\u1eadp m\u1ed9t lo\u1ea1i ion nh\u1ea5t \u0111\u1ecbnh trong qu\u00e1 tr\u00ecnh r\u1eeda gi\u1ea3i v\u00e0 ngay l\u1eadp t\u1ee9c chuy\u1ec3n sang ti\u1ec1n ch\u1ea5t ti\u1ebfp theo.\u00a0Ph\u1ed5 cha m\u1eb9 v\u00e0 m\u1ea3nh \u0111\u01b0\u1ee3c c\u0103n ch\u1ec9nh b\u1edfi c\u00e1c gi\u00e1 tr\u1ecb di \u0111\u1ed9ng.<\/p>\n<p>C\u00f4ng ngh\u1ec7 ph\u00e2n m\u1ea3nh n\u1ed1i ti\u1ebfp t\u00edch l\u0169y song song (PASEF <sup>\u00ae<\/sup>\u00a0) \u0111\u1ea1t \u0111\u01b0\u1ee3c t\u1ed1c \u0111\u1ed9 gi\u1ea3i tr\u00ecnh t\u1ef1 &gt;100 Hz.\u00a0S\u1eed d\u1ee5ng PASEF\u00a0<sup>\u00ae<\/sup> l\u00e0m t\u0103ng ch\u1ea5t l\u01b0\u1ee3ng quang ph\u1ed5 MS\/MS c\u1ee7a c\u00e1c peptide c\u00f3 h\u00e0m l\u01b0\u1ee3ng th\u1ea5p b\u1eb1ng c\u00e1ch ch\u1ecdn ch\u00fang nhi\u1ec1u l\u1ea7n.<\/p>\n<p><strong>PASEF <sup>\u00ae<\/sup>\u00a0: s\u1ef1 ph\u00f9 h\u1ee3p ho\u00e0n h\u1ea3o cho shotgun proteomics<\/strong><br \/>\nTimsTOF SCP \u0111\u01b0\u1ee3c cung c\u1ea5p b\u1edfi PASEF\u00a0<sup>\u00ae<\/sup> cung c\u1ea5p t\u1ed1c \u0111\u1ed9 gi\u1ea3i tr\u00ecnh t\u1ef1 &gt;100 Hz m\u00e0 kh\u00f4ng l\u00e0m gi\u1ea3m \u0111\u1ed9 nh\u1ea1y ho\u1eb7c \u0111\u1ed9 ph\u00e2n gi\u1ea3i.\u00a0\u0110i\u1ec1u n\u00e0y \u0111\u1ea1t \u0111\u01b0\u1ee3c b\u1eb1ng c\u00e1ch \u0111\u1ed3ng b\u1ed9 h\u00f3a c\u1eeda s\u1ed5 kh\u1ed1i c\u00e1ch ly t\u1ee9 c\u1ef1c v\u1edbi th\u1eddi gian r\u1eeda gi\u1ea3i c\u1ee7a c\u00e1c g\u00f3i peptit c\u1ee5 th\u1ec3 t\u1eeb ph\u1ec5u TIMS c\u0169ng nh\u01b0 n\u0103ng l\u01b0\u1ee3ng va ch\u1ea1m trong t\u1ebf b\u00e0o va ch\u1ea1m.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>TimsTOF SCP d\u00e0nh cho nghi\u00ean c\u1ee9u sinh h\u1ecdc t\u1ebf b\u00e0o \u0111\u01a1n \u0111\u1ecbnh l\u01b0\u1ee3ng v\u1edbi 4D-Proteomics\u2122 \u0111\u01a1n t\u1ebf b\u00e0o s\u00e2u, kh\u00f4ng b\u1ecb l\u1ec7ch, mi\u1ec5n d\u1ecbch, bi\u1ec3u sinh v\u00e0 ph\u00e2n t\u00edch PTM \u0111\u1ec3 b\u1ed5 sung cho scRNA-seq. M\u1edf r\u1ed9ng nghi\u00ean c\u1ee9u t\u1ebf b\u00e0o \u0111\u01a1n l\u1ebb.<\/p>\n","protected":false},"featured_media":8631,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[1406],"product_tag":[2632,2678],"class_list":{"0":"post-8666","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-khoi-pho-timstof","7":"product_tag-bruker","8":"product_tag-timstof-scp","9":"yith_product_brand-bruker","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/product\/8666"}],"collection":[{"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/comments?post=8666"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/media\/8631"}],"wp:attachment":[{"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/media?parent=8666"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/product_cat?post=8666"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/product_tag?post=8666"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}