{"id":8622,"date":"2023-06-28T03:24:12","date_gmt":"2023-06-28T03:24:12","guid":{"rendered":"https:\/\/vospan.com\/?post_type=product&#038;p=8622"},"modified":"2024-03-13T08:22:21","modified_gmt":"2024-03-13T08:22:21","slug":"maldi-2-timstof-flex","status":"publish","type":"product","link":"https:\/\/vospan.com\/en\/san-pham\/maldi-2-timstof-flex\/","title":{"rendered":"timsTOF fleX MALDI-2"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_68_1 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<label class=\"ez-toc-title ez-toc-toggle\" style=\"cursor: pointer\">T&oacute;m t\u1eaft n\u1ed9i dung<\/label>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #0a0a0a;color:#0a0a0a\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #0a0a0a;color:#0a0a0a\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/vospan.com\/en\/san-pham\/maldi-2-timstof-flex\/#A_second_laser_is_available_for_post-ionization\" title=\"A second laser is available for post-ionization\">A second laser is available for post-ionization<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/vospan.com\/en\/san-pham\/maldi-2-timstof-flex\/#MALDI-2_and_microGRID_%E2%80%93_A_powerful_combination_making_the_possibility_of_sub-cellular_imaging_within_reach\" title=\"MALDI-2 and microGRID &#8211; A powerful combination making the possibility of sub-cellular imaging within reach\">MALDI-2 and microGRID &#8211; A powerful combination making the possibility of sub-cellular imaging within reach<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/vospan.com\/en\/san-pham\/maldi-2-timstof-flex\/#Post-ionization_is_easily_accessible_via_software_controlled_solutions\" title=\"Post-ionization is easily accessible via software controlled solutions\">Post-ionization is easily accessible via software controlled solutions<\/a><\/li><\/ul><\/nav><\/div>\n<h3 class=\"ui-typography--h2\"><span class=\"ez-toc-section\" id=\"A_second_laser_is_available_for_post-ionization\"><\/span><strong>A second laser is available for post-ionization<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>The overall low ion yield and sensitivity issues due to ion suppression, using traditional MALDI, make the imaging analysis of samples sometimes very challenging. Our answer to these problems is MALDI-2. The post-ionization technique reduces ion suppression effects and improves sensitivity by orders of magnitude.<\/p>\n<p>After the initial MALDI process, a second laser, sitting parallel to the sample surface, fires into the evolving plume and post-ionizes neutral (mainly matrix) molecules. A charge transfer from post-ionized matrix molecules to neutral analyte molecules leads to an amazing sensitivity gain for many analytes.<\/p>\n<h3 class=\"ui-typography--h2\"><span class=\"ez-toc-section\" id=\"MALDI-2_and_microGRID_%E2%80%93_A_powerful_combination_making_the_possibility_of_sub-cellular_imaging_within_reach\"><\/span><strong>MALDI-2 and microGRID &#8211; A powerful combination making the possibility of sub-cellular imaging within reach<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>The need for uncompromising post-ionization has never been greater. High spatial resolution below 10 \u00b5m results in a drastically decrease of ablated and ionized sample material. MALDI-2 post-ionization compensates the lower sample amount per pixel, making even the finest molecular distributions visible.<\/p>\n<p>Combining MALDI-2 post-ionization with microGRID enabled high spatial resolution opens the field for the analysis of the smallest unit of eukaryotic life &#8211; single cells. This unique combination makes the timsTOF fleX MALDI-2 the platform of choice for out of the box single cell imaging.<\/p>\n<figure style=\"width: 619px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"\" src=\"https:\/\/www.bruker.com\/en\/products-and-solutions\/mass-spectrometry\/timstof\/timstof-flex-maldi-2\/_jcr_content\/root\/sections\/features\/sectionpar\/twocolumns\/contentpar-1\/image.coreimg.82.1280.jpeg\/1654097089199\/microgrid-he-image.jpeg\" alt=\"\" width=\"619\" height=\"275\" \/><figcaption class=\"wp-caption-text\">Analyze cell structures that are otherwise only visible with a microscope and obtain molecule-specific information with (sub)cellular resolution.<\/figcaption><\/figure>\n<figure style=\"width: 749px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"\" src=\"https:\/\/www.bruker.com\/en\/products-and-solutions\/mass-spectrometry\/timstof\/timstof-flex-maldi-2\/_jcr_content\/root\/sections\/features\/sectionpar\/twocolumns\/contentpar-2\/image.coreimg.82.1280.jpeg\/1654173305752\/maldi-vs-maldi-2-imaging.jpeg\" alt=\"\" width=\"749\" height=\"638\" \/><figcaption class=\"wp-caption-text\">Complementing microGRID imaging with MALDI-2 post-ionization enhances the sensitivity detecting even the finest molecular distributions.<\/figcaption><\/figure>\n<h3><span class=\"ez-toc-section\" id=\"Post-ionization_is_easily_accessible_via_software_controlled_solutions\"><\/span><strong>Post-ionization is easily accessible via software controlled solutions<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/www.bruker.com\/en\/products-and-solutions\/mass-spectrometry\/timstof\/timstof-flex-maldi-2\/_jcr_content\/root\/sections\/features\/sectionpar\/twocolumns_976027236\/contentpar-2\/image.coreimg.82.1280.jpeg\/1601037505694\/timstof-flex-post-ionization-mode.jpeg\" alt=\"timsTOF fleX MALDI-2 H\u1eadu ion h\u00f3a\" width=\"495\" height=\"286\" \/><\/p>\n<p>The post-ionization laser is built as an add-on to the timsTOF fleX. All functions are exactly the same on the timsTOF fleX MALDI-2. This instrument is build on the latest timsTOF HT technology and combines the most advanced Omics analyses with high sensitive MALDI operation. No physical hardware changes are needed to activate post-ionization.<\/p>\n<p>By just one click in the software the user will be able to change between post-ionization and traditional MALDI mode. This is done in seconds and allows for direct comparison of the two different ionization processes. You do not have to be a professional MALDI operator to use MALDI-2 as it is easy to handle and therefore also suitable for beginners.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>MALDI-2: Bringing enhanced Sensitivity and Dimensionality<\/p>\n","protected":false},"featured_media":8624,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_cat":[1404],"product_tag":[2634,2688],"class_list":{"0":"post-8622","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-timstof","7":"product_tag-bruker-en","8":"product_tag-timstof-flex-maldi-2-en","9":"yith_product_brand-bruker-en","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/product\/8622"}],"collection":[{"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/comments?post=8622"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/media\/8624"}],"wp:attachment":[{"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/media?parent=8622"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/product_cat?post=8622"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/product_tag?post=8622"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}