{"id":9125,"date":"2023-07-21T07:40:05","date_gmt":"2023-07-21T07:40:05","guid":{"rendered":"https:\/\/vospan.com\/?p=9125"},"modified":"2024-03-20T08:18:22","modified_gmt":"2024-03-20T08:18:22","slug":"gia-tri-cua-cong-nghe-maldi-tof-trong-nhan-dang-cap-do-loai","status":"publish","type":"post","link":"https:\/\/vospan.com\/gia-tri-cua-cong-nghe-maldi-tof-trong-nhan-dang-cap-do-loai\/","title":{"rendered":"C\u00f4ng ngh\u1ec7 kh\u1ed1i ph\u1ed5 MALDI-TOF v\u1edbi h\u1ec7 th\u1ed1ng \u0111\u1ecbnh danh vi sinh v\u1eadt nhanh ch\u00f3ng"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_68_1 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<label class=\"ez-toc-title ez-toc-toggle\" style=\"cursor: pointer\">T&oacute;m t\u1eaft n\u1ed9i dung<\/label>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #0a0a0a;color:#0a0a0a\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #0a0a0a;color:#0a0a0a\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/vospan.com\/gia-tri-cua-cong-nghe-maldi-tof-trong-nhan-dang-cap-do-loai\/#Cong_nghe_khoi_pho_MALDI-TOF_la_gi\" title=\"C\u00f4ng ngh\u1ec7 kh\u1ed1i ph\u1ed5 MALDI-TOF l\u00e0 g\u00ec?\">C\u00f4ng ngh\u1ec7 kh\u1ed1i ph\u1ed5 MALDI-TOF l\u00e0 g\u00ec?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/vospan.com\/gia-tri-cua-cong-nghe-maldi-tof-trong-nhan-dang-cap-do-loai\/#Tam_quan_trong_cua_viec_xac_dinh_cap_do_loai_trong_duoc_pham\" title=\"T\u1ea7m quan tr\u1ecdng c\u1ee7a vi\u1ec7c x\u00e1c \u0111\u1ecbnh c\u1ea5p \u0111\u1ed9 lo\u00e0i trong d\u01b0\u1ee3c ph\u1ea9m\">T\u1ea7m quan tr\u1ecdng c\u1ee7a vi\u1ec7c x\u00e1c \u0111\u1ecbnh c\u1ea5p \u0111\u1ed9 lo\u00e0i trong d\u01b0\u1ee3c ph\u1ea9m<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/vospan.com\/gia-tri-cua-cong-nghe-maldi-tof-trong-nhan-dang-cap-do-loai\/#Uu_diem_cua_cong_nghe_khoi_pho_MALDI-TOF\" title=\"\u01afu \u0111i\u1ec3m c\u1ee7a c\u00f4ng ngh\u1ec7 kh\u1ed1i ph\u1ed5 MALDI-TOF\">\u01afu \u0111i\u1ec3m c\u1ee7a c\u00f4ng ngh\u1ec7 kh\u1ed1i ph\u1ed5 MALDI-TOF<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/vospan.com\/gia-tri-cua-cong-nghe-maldi-tof-trong-nhan-dang-cap-do-loai\/#VITEK%C2%AE_MS_PRIME_voi_cong_nghe_khoi_pho_MALDI-TOF\" title=\"VITEK\u00ae MS PRIME v\u1edbi c\u00f4ng ngh\u1ec7 kh\u1ed1i ph\u1ed5 MALDI-TOF\u00a0\">VITEK\u00ae MS PRIME v\u1edbi c\u00f4ng ngh\u1ec7 kh\u1ed1i ph\u1ed5 MALDI-TOF\u00a0<\/a><\/li><\/ul><\/nav><\/div>\n<p>C\u00f4ng ngh\u1ec7 kh\u1ed1i ph\u1ed5 MALDI-TOF mang l\u1ea1i h\u1ec7 th\u1ed1ng \u0111\u1ecbnh danh vi sinh v\u1eadt t\u1ef1 \u0111\u1ed9ng v\u1edbi c\u01a1 s\u1edf d\u1eef li\u1ec7u m\u1ea1nh m\u1ebd, gi\u1ea3m th\u1eddi gian ch\u1edd k\u1ebft qu\u1ea3 xu\u1ed1ng c\u00f2n v\u00e0i ph\u00fat, \u0111i\u1ec1u n\u00e0y c\u1ef1c k\u1ef3 c\u00f3 \u00fd ngh\u0129a trong vi\u1ec7c ph\u00e1t hi\u1ec7n v\u00e0 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh tr\u00ean \u0111\u1ed9ng v\u1eadt thu\u1ef7 s\u1ea3n.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Cong_nghe_khoi_pho_MALDI-TOF_la_gi\"><\/span><b>C\u00f4ng ngh\u1ec7 kh\u1ed1i ph\u1ed5 MALDI-TOF l\u00e0 g\u00ec?<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Ph\u01b0\u01a1ng ph\u00e1p ion h\u00f3a m\u1eabu h\u1ea5p th\u1ee5 d\u1ef1a tr\u00ean s\u1ef1 h\u1ed7 tr\u1ee3 c\u1ee7a c\u00e1c ch\u1ea5t n\u1ec1n v\u00e0 n\u0103ng l\u01b0\u1ee3ng laser (MALDI) s\u1eed d\u1ee5ng tia laser \u0111\u1ec3 h\u1ea5p th\u1ee5 n\u0103ng l\u01b0\u1ee3ng t\u1eeb ch\u1ea5t n\u1ec1n nh\u1eb1m t\u1ea1o ra c\u00e1c ion v\u1edbi s\u1ef1 ph\u00e2n m\u1ea3nh t\u1ed1i thi\u1ec3u t\u1eeb c\u00e1c ph\u00e2n t\u1eed l\u1edbn. N\u00f3 c\u00f3 th\u1ec3 ph\u00e2n t\u00edch c\u00e1c polyme sinh h\u1ecdc nh\u01b0 DNA, protein, peptide, carbohydrate v\u00e0 c\u00e1c \u0111\u1ea1i ph\u00e2n t\u1eed h\u1eefu c\u01a1 kh\u00e1c.\u00a0Trong ph\u00e9p \u0111o kh\u1ed1i ph\u1ed5 th\u1eddi gian bay (TOF) MALDI (MS), m\u00e1y ph\u00e2n t\u00edch TOF \u0111o t\u1ef7 l\u1ec7 kh\u1ed1i l\u01b0\u1ee3ng tr\u00ean \u0111i\u1ec7n t\u00edch (m\/z) c\u1ee7a c\u00e1c ph\u00e2n t\u1eed t\u00edch \u0111i\u1ec7n.<\/p>\n<p>\u0110i\u1ec1u c\u1ea7n thi\u1ebft l\u00e0 x\u00e1c \u0111\u1ecbnh v\u00e0 ph\u00e2n bi\u1ec7t vi khu\u1ea9n khi ti\u1ebfn h\u00e0nh c\u00e1c x\u00e9t nghi\u1ec7m \u0111\u1ec3 ch\u1ea9n \u0111o\u00e1n b\u1ec7nh, x\u00e1c \u0111\u1ecbnh ngu\u1ed3n l\u00e2y nhi\u1ec5m ho\u1eb7c nghi\u00ean c\u1ee9u t\u00e1c \u0111\u1ed9ng c\u1ee7a c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ho\u1eb7c \u0111i\u1ec1u ki\u1ec7n m\u00f4i tr\u01b0\u1eddng \u0111\u1ed1i v\u1edbi qu\u1ea7n th\u1ec3 vi sinh v\u1eadt. MALDI-TOF MS l\u00e0 m\u1ed9t trong nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p proteomics m\u1ea1nh m\u1ebd nh\u1ea5t v\u00e0 l\u00e0 c\u00e1ch nhanh ch\u00f3ng, ch\u00ednh x\u00e1c v\u00e0 ti\u1ebft ki\u1ec7m \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh v\u00e0 ph\u00e2n bi\u1ec7t c\u00e1c vi khu\u1ea9n, ch\u1eb3ng h\u1ea1n nh\u01b0 vi khu\u1ea9n, vi r\u00fat, k\u00fd sinh tr\u00f9ng v\u00e0 n\u1ea5m. C\u00f4ng ngh\u1ec7 n\u00e0y t\u1ea1o ra c\u00e1c d\u1ea5u v\u00e2n tay ph\u1ed5 kh\u1ed1i ri\u00eang cho t\u1eebng vi sinh v\u1eadt v\u00e0 do \u0111\u00f3 c\u00f3 th\u1ec3 x\u00e1c \u0111\u1ecbnh ch\u00fang m\u1ed9t c\u00e1ch ch\u00ednh x\u00e1c \u1edf c\u1ea5p \u0111\u1ed9 chi v\u00e0 lo\u00e0i.<\/p>\n<p>MALDI-TOF MS so s\u00e1nh quang ph\u1ed5 t\u1eeb c\u00e1c t\u1ebf b\u00e0o nguy\u00ean v\u1eb9n t\u1ea1o ra v\u1edbi c\u01a1 s\u1edf d\u1eef li\u1ec7u d\u1ea5u v\u00e2n tay m\u1ed9t c\u00e1ch \u0111\u01a1n gi\u1ea3n v\u00e0 nhanh ch\u00f3ng, khi\u1ebfn n\u00f3 tr\u1edf n\u00ean l\u00fd t\u01b0\u1edfng \u0111\u1ec3 s\u1eed d\u1ee5ng trong m\u00f4i tr\u01b0\u1eddng ph\u00f2ng th\u00ed nghi\u1ec7m ch\u1ea9n \u0111o\u00e1n. C\u01a1 s\u1edf d\u1eef li\u1ec7u \u0111\u01b0\u1ee3c l\u01b0u gi\u1eef c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh c\u00e1c lo\u00e0i v\u00e0 ph\u00e2n lo\u00e0i b\u1ea5t k\u1ec3 c\u00e1c \u0111i\u1ec1u ki\u1ec7n nu\u00f4i c\u1ea5y \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 nu\u00f4i c\u1ea5y vi sinh v\u1eadt.<\/p>\n<p>M\u1ed9t t\u00ednh n\u0103ng kh\u00e1c c\u1ee7a MALDI-TOF MS li\u00ean quan \u0111\u1ebfn k\u1ebft n\u1ed1i kh\u1ed1i l\u01b0\u1ee3ng d\u1ea5u \u1ea5n sinh h\u1ecdc v\u1edbi c\u01a1 s\u1edf d\u1eef li\u1ec7u h\u1ec7 protein: protein l\u00e0 ph\u00e2n t\u1eed sinh h\u1ecdc \u0111\u01b0\u1ee3c quan s\u00e1t nhi\u1ec1u nh\u1ea5t v\u1edbi t\u1ef7 l\u1ec7 kh\u1ed1i l\u01b0\u1ee3ng tr\u00ean \u0111i\u1ec7n t\u00edch l\u1edbn h\u01a1n 4000 m\/z trong quang ph\u1ed5 MALDI-TOF thu \u0111\u01b0\u1ee3c t\u1eeb chi\u1ebft xu\u1ea5t to\u00e0n t\u1ebf b\u00e0o. Do \u0111\u00f3, c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n kh\u1ed1i l\u01b0\u1ee3ng protein t\u1eeb b\u1ed9 gen \u0111\u01b0\u1ee3c gi\u1ea3i tr\u00ecnh t\u1ef1 v\u00e0 t\u00ecm ki\u1ebfm c\u00e1c k\u1ebft qu\u1ea3 ph\u00f9 h\u1ee3p v\u1edbi kh\u1ed1i l\u01b0\u1ee3ng c\u00f3 ngu\u1ed3n g\u1ed1c th\u1ef1c nghi\u1ec7m. Ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn d\u1ef1a tr\u00ean tin sinh h\u1ecdc n\u00e0y \u01b0u vi\u1ec7t h\u01a1n so v\u1edbi ph\u01b0\u01a1ng ph\u00e1p l\u1ea5y d\u1ea5u v\u00e2n tay vi khu\u1ea9n, v\u00ec n\u00f3 c\u00f3 th\u1ec3 x\u00e1c \u0111\u1ecbnh vi khu\u1ea9n m\u1eb7c d\u00f9 c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 c\u1ea5u h\u00ecnh protein, s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a m\u00f4i tr\u01b0\u1eddng nu\u00f4i c\u1ea5y v\u00e0 \u0111i\u1ec1u ki\u1ec7n x\u1eed l\u00fd m\u1eabu. N\u00f3 c\u0169ng c\u00f3 th\u1ec3 ph\u00e1t hi\u1ec7n \u0111\u1ed9c t\u1ed1 vi sinh v\u1eadt v\u00e0 ph\u00e2n t\u00edch kh\u1ea3 n\u0103ng kh\u00e1ng kh\u00e1ng sinh.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Tam_quan_trong_cua_viec_xac_dinh_cap_do_loai_trong_duoc_pham\"><\/span><b>T\u1ea7m quan tr\u1ecdng c\u1ee7a vi\u1ec7c x\u00e1c \u0111\u1ecbnh c\u1ea5p \u0111\u1ed9 lo\u00e0i trong d\u01b0\u1ee3c ph\u1ea9m<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"text cmp-text--article aem-GridColumn aem-GridColumn--default--12\">Gi\u1edbi t\u00ednh c\u1ee7a m\u1ed9t sinh v\u1eadt kh\u00f4ng ph\u1ea3i l\u00e0 m\u1ed9t ch\u1ec9 s\u1ed1 ch\u00ednh x\u00e1c v\u1ec1 lo\u00e0i c\u1ee7a n\u00f3. Theo \u0111\u00f3, ch\u1ec9 x\u00e1c \u0111\u1ecbnh gi\u1edbi t\u00ednh l\u00e0 kh\u00f4ng \u0111\u1ee7 khi \u0111\u00e1nh gi\u00e1 vi sinh v\u1eadt do s\u1ef1 t\u01b0\u01a1ng t\u00e1c c\u1ee7a c\u1ed9ng \u0111\u1ed3ng vi sinh v\u1eadt v\u1edbi m\u00f4i tr\u01b0\u1eddng ng\u00e0y c\u00e0ng ph\u1ee9c t\u1ea1p. Trong c\u00f9ng m\u1ed9t lo\u1ea1i vi khu\u1ea9n, m\u1ed9t lo\u00e0i c\u00f3 th\u1ec3 c\u1ef1c k\u1ef3 quan tr\u1ecdng. Vi\u1ec7c x\u00e1c \u0111\u1ecbnh lo\u00e0i vi sinh v\u1eadt s\u1ebd ph\u00e1t hi\u1ec7n \u0111\u01b0\u1ee3c nguy\u00ean nh\u00e2n g\u1ed1c r\u1ec5 g\u00e2y l\u00e2y nhi\u1ec5m. C\u00e1ch ti\u1ebfp c\u1eadn n\u00e0y ph\u00f9 h\u1ee3p v\u1edbi c\u00e1c khuy\u1ebfn ngh\u1ecb m\u1edbi nh\u1ea5t v\u1ec1 Ti\u00eau chu\u1ea9n Th\u1ef1c h\u00e0nh S\u1ea3n xu\u1ea5t T\u1ed1t (GMP) c\u1ee7a Ch\u00e2u \u00c2u. H\u01b0\u1edbng d\u1eabn n\u00eau r\u00f5 r\u1eb1ng t\u1ea5t c\u1ea3 c\u00e1c vi sinh v\u1eadt \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong khu v\u1ef1c H\u1ea1ng A (khu v\u1ef1c ho\u1ea1t \u0111\u1ed9ng c\u00f3 r\u1ee7i ro cao, ch\u1eb3ng h\u1ea1n nh\u01b0 d\u00e2y chuy\u1ec1n ch\u1ebf bi\u1ebfn v\u00f4 tr\u00f9ng) ho\u1eb7c khu v\u1ef1c H\u1ea1ng B (ph\u00f2ng s\u1ea1ch n\u1ec1n cho khu v\u1ef1c H\u1ea1ng A) ph\u1ea3i \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh theo lo\u00e0i c\u1ee7a ch\u00fang v\u00e0 c\u0169ng c\u1ea7n thi\u1ebft l\u1eadp \u1ea3nh h\u01b0\u1edfng ti\u1ec1m \u1ea9n c\u1ee7a ch\u00fang \u0111\u1ed1i v\u1edbi ch\u1ea5t l\u01b0\u1ee3ng s\u1ea3n ph\u1ea9m (\u0111\u1ed1i v\u1edbi c\u00e1c l\u00f4 t\u01b0\u01a1ng \u1ee9ng) v\u00e0 ki\u1ec3m so\u00e1t s\u1ea3n xu\u1ea5t. H\u01b0\u1edbng d\u1eabn c\u0169ng khuy\u00ean r\u1eb1ng \u0111i\u1ec1u c\u1ea7n thi\u1ebft l\u00e0 x\u00e1c \u0111\u1ecbnh v\u00e0 xem x\u00e9t c\u00e1c vi sinh v\u1eadt \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y \u1edf c\u00e1c khu v\u1ef1c H\u1ea1ng C v\u00e0 H\u1ea1ng D (ph\u00f2ng s\u1ea1ch \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh cho c\u00e1c giai \u0111o\u1ea1n \u00edt quan tr\u1ecdng h\u01a1n c\u1ee7a quy tr\u00ecnh s\u1ea3n xu\u1ea5t, ch\u1eb3ng h\u1ea1n nh\u01b0 chu\u1ea9n b\u1ecb dung d\u1ecbch) khi v\u01b0\u1ee3t qu\u00e1 gi\u1edbi h\u1ea1n h\u00e0nh \u0111\u1ed9ng ho\u1eb7c m\u1ee9c c\u1ea3nh b\u00e1o ho\u1eb7c sau khi ph\u00e2n l\u1eadp c\u00e1c sinh v\u1eadt c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn gi\u1ea3m kh\u1ea3 n\u0103ng ki\u1ec3m so\u00e1t, thi\u1ebfu \u0111\u1ed9 s\u1ea1ch ho\u1eb7c kh\u00f3 ki\u1ec3m so\u00e1t, ch\u1eb3ng h\u1ea1n nh\u01b0 vi sinh v\u1eadt h\u00ecnh th\u00e0nh b\u00e0o t\u1eed v\u00e0 n\u1ea5m m\u1ed1c v\u00e0 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ea5t l\u01b0\u1ee3ng s\u1ea3n ph\u1ea9m (\u0111\u1ed1i v\u1edbi c\u00e1c l\u00f4 t\u01b0\u01a1ng \u1ee9ng) v\u00e0 ki\u1ec3m so\u00e1t s\u1ea3n xu\u1ea5t c\u0169ng c\u1ea7n \u0111\u01b0\u1ee3c thi\u1ebft l\u1eadp.<\/p>\n<h2 class=\"text cmp-text--article aem-GridColumn aem-GridColumn--default--12\"><span class=\"ez-toc-section\" id=\"Uu_diem_cua_cong_nghe_khoi_pho_MALDI-TOF\"><\/span><b>\u01afu \u0111i\u1ec3m c\u1ee7a c\u00f4ng ngh\u1ec7 kh\u1ed1i ph\u1ed5 MALDI-TOF<\/b><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p class=\"text cmp-text--article aem-GridColumn aem-GridColumn--default--12\">K\u1ef9 thu\u1eadt MALDI-TOF c\u00f3 th\u1ec3 \u0111\u00e1nh gi\u00e1 vi khu\u1ea9n Gram d\u01b0\u01a1ng, Gram \u00e2m, n\u1ea5m m\u1ed1c, mycobacteria v\u00e0 vi khu\u1ea9n k\u1ef5 kh\u00ed, cung c\u1ea5p th\u00f4ng tin chi ti\u1ebft c\u1ea7n thi\u1ebft \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh ch\u00ednh x\u00e1c t\u00ecnh tr\u1ea1ng nhi\u1ec5m vi khu\u1ea9n. C\u00e1c \u1ee9ng d\u1ee5ng bao g\u1ed3m ph\u00e1t hi\u1ec7n s\u1edbm vi sinh v\u1eadt tr\u00ean d\u00e2y chuy\u1ec1n s\u1ea3n xu\u1ea5t d\u01b0\u1ee3c ph\u1ea9m ho\u1eb7c ph\u00f2ng th\u00ed nghi\u1ec7m. K\u1ef9 thu\u1eadt MALDI-TOF c\u00f3 th\u1ec3 gi\u00fap ng\u0103n ng\u1eeba nhi\u1ec5m b\u1ea9n, ti\u1ebft ki\u1ec7m th\u1eddi gian, chi ph\u00ed v\u00e0 th\u00fac \u0111\u1ea9y d\u00e2y chuy\u1ec1n s\u1ea3n xu\u1ea5t nhanh ch\u00f3ng. M\u1ed9t nghi\u00ean c\u1ee9u so s\u00e1nh nh\u1eadn \u0111\u1ecbnh r\u1eb1ng c\u00f4ng ngh\u1ec7 kh\u1ed1i ph\u1ed5 MALDI-TOF \u0111\u00e3 gi\u1ea3m th\u1eddi gian cho k\u1ebft qu\u1ea3 t\u1eeb 24 \u0111\u1ebfn 48 gi\u1edd xu\u1ed1ng d\u01b0\u1edbi 30 ph\u00fat. \u0110i\u1ec1u n\u00e0y cho ph\u00e9p th\u1ef1c hi\u1ec7n c\u00e1c bi\u1ec7n ph\u00e1p ki\u1ec3m so\u00e1t vi sinh nhanh ch\u00f3ng, \u0111\u01b0a ra k\u1ebft qu\u1ea3 ch\u00ednh x\u00e1c h\u01a1n cho ng\u00e0nh d\u01b0\u1ee3c ph\u1ea9m.<\/p>\n<p>C\u00f4ng ngh\u1ec7 kh\u1ed1i ph\u1ed5 MALDI-TOF c\u0169ng c\u00f3 th\u1ec3 ph\u00e1t hi\u1ec7n nhi\u1ec1u t\u1ea1p ch\u1ea5t trong m\u1ed9t m\u1eabu duy nh\u1ea5t, lo\u1ea1i b\u1ecf s\u1ef1 ch\u1eadm tr\u1ec5 m\u00e0 kh\u00f4ng l\u00e0m t\u0103ng chi ph\u00ed ho\u1eb7c c\u00e1c b\u01b0\u1edbc b\u1ed5 sung trong quy tr\u00ecnh: MALDI-TOF cho ph\u00e9p t\u1ef1 ki\u1ec3m tra v\u00e0 gi\u1ea3m chi ph\u00ed th\u00f4ng qua qu\u00e1 tr\u00ecnh \u0111\u1ecbnh danh n\u1ed9i b\u1ed9. M\u1ed9t nghi\u00ean c\u1ee9u so s\u00e1nh \u01b0\u1edbc t\u00ednh r\u1eb1ng vi\u1ec7c x\u00e1c \u0111\u1ecbnh MALDI-TOF c\u1ea7n th\u1eddi gian trung b\u00ecnh l\u00e0 6 ph\u00fat \u0111\u1ec3 gi\u1ea3m kho\u1ea3ng 70 \u0111\u1ebfn 80% chi ph\u00ed so v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p th\u00f4ng th\u01b0\u1eddng. M\u1ed9t ph\u01b0\u01a1ng ph\u00e1p thay th\u1ebf, ch\u1eb3ng h\u1ea1n nh\u01b0 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p d\u1ef1a tr\u00ean axit nucleic, \u0111\u1eaft ti\u1ec1n, t\u1ed1n th\u1eddi gian v\u00e0 \u00edt th\u1ef1c t\u1ebf h\u01a1n so v\u1edbi MS \u0111\u1ec3 ph\u00e1t hi\u1ec7n v\u00e0 ph\u00e2n t\u00edch trong ph\u00f2ng th\u00ed nghi\u1ec7m th\u00f4ng th\u01b0\u1eddng.<\/p>\n<h2 class=\"product-title product_title entry-title\"><span class=\"ez-toc-section\" id=\"VITEK%C2%AE_MS_PRIME_voi_cong_nghe_khoi_pho_MALDI-TOF\"><\/span><strong><a href=\"https:\/\/vospan.com\/san-pham\/vitek-ms-prime-may-dinh-danh-vi-sinh-vat-cong-nghe-khoi-pho-maldi-tof\/\">VITEK\u00ae MS PRIME<\/a> v\u1edbi c\u00f4ng ngh\u1ec7 kh\u1ed1i ph\u1ed5 MALDI-TOF\u00a0<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>bioM\u00e9rieux c\u00f3 h\u01a1n 50 n\u0103m kinh nghi\u1ec7m v\u1ec1 l\u0129nh v\u1ef1c vi sinh v\u00e0 \u0111\u00e3 s\u1eed d\u1ee5ng chuy\u00ean m\u00f4n n\u00e0y \u0111\u1ec3 ph\u00e1t tri\u1ec3n h\u1ec7 th\u1ed1ng MALDI-TOF t\u1ef1 \u0111\u1ed9ng \u0111\u00e1p \u1ee9ng c\u00e1c th\u00e1ch th\u1ee9c v\u1ec1 ki\u1ec3m so\u00e1t ch\u1ea5t l\u01b0\u1ee3ng vi sinh. C\u1ea3 tia laser v\u00e0 ph\u01b0\u01a1ng ph\u00e1p b\u1eafn tia laser \u0111\u1ec1u \u0111\u00e3 \u0111\u01b0\u1ee3c ho\u00e0n thi\u1ec7n \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o x\u00e1c \u0111\u1ecbnh lo\u00e0i vi sinh v\u1eadt.<\/p>\n<p>C\u01a1 s\u1edf d\u1eef li\u1ec7u m\u1ea1nh m\u1ebd c\u00f3 t\u00ednh \u0111a d\u1ea1ng v\u1ec1 lo\u00e0i, t\u1ea1o \u0111i\u1ec1u ki\u1ec7n cho hi\u1ec7u su\u1ea5t x\u00e1c \u0111\u1ecbnh lo\u00e0i n\u00e2ng cao, bao g\u1ed3m <i>Escherichia coli, Pseudomonas aeruginosa, Candida albicans<\/i>\u00a0v\u00e0\u00a0<i>Aspergillus brasiliensis<\/i> .\u00a0C\u1ea3i ti\u1ebfn m\u1edbi nh\u1ea5t c\u1ee7a bioM\u00e9rieux t\u1eadp trung v\u00e0o n\u1ea5m m\u1ed1c, vi khu\u1ea9n mycobacteria v\u00e0 nhi\u1ec1u lo\u00e0i vi khu\u1ea9n quan tr\u1ecdng, b\u1ed5 sung th\u00eam 286 lo\u00e0i cho 186 lo\u00e0i vi khu\u1ea9n v\u00e0 107 lo\u00e0i n\u1ea5m. C\u00e1c thu\u1eadt to\u00e1n c\u0169ng \u0111\u01b0\u1ee3c thay \u0111\u1ed5i cho ph\u00e9p ph\u00e2n bi\u1ec7t gi\u1eefa c\u00e1c lo\u00e0i kh\u00e9p k\u00edn nh\u01b0 <i>Bacillus cereus<\/i>\u00a0v\u00e0\u00a0<i>Bacillus thuringiensis<\/i>\u00a0.<\/p>\n<p>C\u01a1 s\u1edf d\u1eef li\u1ec7u\u00a0<strong><a href=\"https:\/\/vospan.com\/san-pham\/vitek-ms-prime-may-dinh-danh-vi-sinh-vat-cong-nghe-khoi-pho-maldi-tof\/\">VITEK\u00a0<sup>\u00ae<\/sup> MS PRIME<\/a> hi\u1ec7n cho ph\u00e9p x\u00e1c \u0111\u1ecbnh 1.585 lo\u00e0i<\/strong>, bao g\u1ed3m 16.000 ch\u1ee7ng vi khu\u1ea9n, n\u1ea5m men v\u00e0 n\u1ea5m m\u1ed1c trong v\u00f2ng v\u00e0i ph\u00fat. V\u1edbi trung b\u00ecnh 12 ch\u1ee7ng tr\u00ean m\u1ed7i lo\u00e0i v\u00e0 n\u00e2ng cao hi\u1ec7u qu\u1ea3 quy tr\u00ecnh l\u00e0m vi\u1ec7c, <a href=\"https:\/\/vospan.com\/san-pham\/vitek-ms-prime-may-dinh-danh-vi-sinh-vat-cong-nghe-khoi-pho-maldi-tof\/\">VITEK\u00ae MS PRIME<\/a> \u0111\u1ea3m b\u1ea3o x\u00e1c \u0111\u1ecbnh lo\u00e0i ch\u00ednh x\u00e1c v\u00e0 m\u1ea1nh m\u1ebd.<\/p>\n<p>C\u1ea5u tr\u00fac c\u01a1 s\u1edf d\u1eef li\u1ec7u bioM\u00e9rieux n\u00e2ng cao hi\u1ec7u su\u1ea5t x\u00e1c \u0111\u1ecbnh lo\u00e0i cho m\u1ed9t nh\u00f3m d\u01b0\u1ee3c ph\u1ea9m quan tr\u1ecdng: m\u1ed9t nghi\u00ean c\u1ee9u s\u1eed d\u1ee5ng MALDI-TOF MS \u0111\u1ec3 ph\u00e2n bi\u1ec7t c\u00e1c nh\u00f3m <i>Bacillus cereus<\/i>\u00a0v\u00e0\u00a0<i>Bacillus subtilis<\/i> \u0111\u00e3 \u0111\u01b0a ra k\u1ebft qu\u1ea3 c\u00f3 \u0111\u1ed9 ch\u00ednh x\u00e1c cao trong vi\u1ec7c ph\u00e2n bi\u1ec7t gi\u1eefa c\u00e1c lo\u00e0i n\u00e0y m\u00e0 kh\u00f4ng c\u1ea7n b\u1ea5t k\u1ef3 b\u01b0\u1edbc chi\u1ebft xu\u1ea5t n\u00e0o. C\u01a1 s\u1edf d\u1eef li\u1ec7u \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong nghi\u00ean c\u1ee9u n\u00e0y bao g\u1ed3m 2.745 ph\u1ed5 tham chi\u1ebfu t\u1eeb 117 lo\u00e0i thu\u1ed9c chi <i>Bacillus<\/i>\u00a0v\u00e0 c\u00e1c lo\u00e0i li\u00ean quan.\u00a0Kh\u00f4ng c\u00f3 h\u1ec7 th\u1ed1ng MS n\u00e0o kh\u00e1c c\u00f3 th\u1ec3 ph\u00e2n bi\u1ec7t c\u00e1c lo\u00e0i n\u00e0y trong th\u1eed nghi\u1ec7m th\u00f4ng th\u01b0\u1eddng.<\/p>\n<div class=\"image aem-GridColumn--default--none aem-GridColumn aem-GridColumn--default--8 aem-GridColumn--offset--default--2\">\n<div id=\"image-cae9763dde\" class=\"cmp-image\" data-cmp-widths=\"320,480,600,800,1024,1200,1600\" data-cmp-dmimage=\"\" data-cmp-src=\"https:\/\/s7g10.scene7.com\/is\/image\/biomerieux\/bidimensional%20spectra%20distribution%20MALDI%20TOF?qlt=85&amp;wid=%7B.width%7D&amp;ts=1689769643557&amp;dpr=off\" data-cmp-data-layer=\"{&quot;image-cae9763dde&quot;:{&quot;@type&quot;:&quot;onebmx\/components\/image&quot;,&quot;repo:modifyDate&quot;:&quot;2023-07-19T12:27:23Z&quot;,&quot;image&quot;:{&quot;repo:id&quot;:&quot;75bc754b-daef-484e-9140-39c7e6f14ff6&quot;,&quot;repo:modifyDate&quot;:&quot;2023-07-19T09:36:37Z&quot;,&quot;@type&quot;:&quot;image\/jpeg&quot;,&quot;repo:path&quot;:&quot;\/content\/dam\/biomerieux-com\/03----our-offer\/pharma-resources\/scientific-library-pharma\/bidimensional spectra distribution MALDI TOF.jpg&quot;,&quot;xdm:smartTags&quot;:{&quot;template&quot;:0.8119146227836609,&quot;layout&quot;:0.7685240507125854,&quot;website&quot;:0.7586606740951538,&quot;business&quot;:0.753955602645874,&quot;web&quot;:0.8028881549835205,&quot;design&quot;:0.7752757668495178,&quot;vector&quot;:0.7982978820800781}}}}\" data-cmp-hook-image=\"imageV3\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/s7g10.scene7.com\/is\/image\/biomerieux\/bidimensional%20spectra%20distribution%20MALDI%20TOF?qlt=85&amp;ts=1689769643557&amp;dpr=off\" alt=\"C\u00f4ng ngh\u1ec7 kh\u1ed1i ph\u1ed5 MALDI-TOF\" width=\"400\" height=\"250\" \/><\/div>\n<\/div>\n<div class=\"text aem-GridColumn aem-GridColumn--default--12\">\n<div id=\"text-92826c1392\" class=\"cmp-text\" style=\"font-size: var(--font-text-rg);\" data-cmp-data-layer=\"{&quot;text-92826c1392&quot;:{&quot;@type&quot;:&quot;onebmx\/components\/text&quot;,&quot;repo:modifyDate&quot;:&quot;2023-07-19T12:28:55Z&quot;,&quot;xdm:text&quot;:&quot;&lt;p&gt;It appears that all species within the &lt;i&gt;Bacillus subtilis&lt;\/i&gt; and &lt;i&gt;Bacillus cereus&lt;\/i&gt; groups are easily distinguishable, except for &lt;i&gt;Bacillus weihenstephanensis&lt;\/i&gt; and &lt;i&gt;Bacillus mycoides&lt;\/i&gt; in the &lt;i&gt;Bacillus cereus&lt;\/i&gt; group, which overlap.&lt;\/p&gt;\\r\\n&quot;}}\">\n<p>D\u01b0\u1eddng nh\u01b0 t\u1ea5t c\u1ea3 c\u00e1c lo\u00e0i trong nh\u00f3m\u00a0<i>Bacillus subtilis<\/i>\u00a0v\u00e0\u00a0<i>Bacillus cereus<\/i>\u00a0\u0111\u1ec1u c\u00f3 th\u1ec3 d\u1ec5 d\u00e0ng ph\u00e2n bi\u1ec7t, ngo\u1ea1i tr\u1eeb\u00a0<i>Bacillus weihenstephanensis<\/i>\u00a0v\u00e0\u00a0<i>Bacillus mycoides<\/i>\u00a0trong nh\u00f3m\u00a0<i>Bacillus cereus<\/i>\u00a0tr\u00f9ng nhau.<\/p>\n<\/div>\n<\/div>\n<div class=\"image aem-GridColumn--default--none aem-GridColumn aem-GridColumn--default--8 aem-GridColumn--offset--default--2\">\n<div id=\"image-ed10c05ff6\" class=\"cmp-image\" data-cmp-widths=\"320,480,600,800,1024,1200,1600\" data-cmp-dmimage=\"\" data-cmp-src=\"https:\/\/s7g10.scene7.com\/is\/image\/biomerieux\/species%20identification%20MALDI%20TOF?qlt=85&amp;wid=%7B.width%7D&amp;ts=1689769899526&amp;dpr=off\" data-cmp-data-layer=\"{&quot;image-ed10c05ff6&quot;:{&quot;@type&quot;:&quot;onebmx\/components\/image&quot;,&quot;repo:modifyDate&quot;:&quot;2023-07-19T12:31:39Z&quot;,&quot;image&quot;:{&quot;repo:id&quot;:&quot;9683f039-6828-4dac-bba3-ef8b9457b9a9&quot;,&quot;repo:modifyDate&quot;:&quot;2023-07-19T09:36:31Z&quot;,&quot;@type&quot;:&quot;image\/jpeg&quot;,&quot;repo:path&quot;:&quot;\/content\/dam\/biomerieux-com\/03----our-offer\/pharma-resources\/scientific-library-pharma\/species identification MALDI TOF.jpg&quot;,&quot;xdm:smartTags&quot;:{&quot;calendar&quot;:0.8603745698928833,&quot;date&quot;:0.7697063684463501,&quot;year&quot;:0.7515950798988342}}}}\" data-cmp-hook-image=\"imageV3\"><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/s7g10.scene7.com\/is\/image\/biomerieux\/species%20identification%20MALDI%20TOF?qlt=85&amp;ts=1689769899526&amp;dpr=off\" \/><\/div>\n<\/div>\n<div class=\"text aem-GridColumn aem-GridColumn--default--12\">\n<div id=\"text-6b9c7f668d\" class=\"cmp-text\" style=\"font-size: var(--font-text-rg);\" data-cmp-data-layer=\"{&quot;text-6b9c7f668d&quot;:{&quot;@type&quot;:&quot;onebmx\/components\/text&quot;,&quot;repo:modifyDate&quot;:&quot;2023-07-19T12:35:15Z&quot;,&quot;xdm:text&quot;:&quot;&lt;p&gt;The VITEK&lt;sup&gt;\u00ae&lt;\/sup&gt; MS PRIME algorithm enables accurate discrimination of all species within the &lt;i&gt;Bacillus cereus&lt;\/i&gt; and &lt;i&gt;Bacillus subtilis&lt;\/i&gt; groups, with performance ranging from 98 to 100%, and confirms the close relation between &lt;i&gt;Bacillus weihenstephanensis &lt;\/i&gt;and &lt;i&gt;Bacillus mycoides&lt;\/i&gt; with relatively low discrimination.&lt;\/p&gt;\\r\\n&lt;p&gt;&amp;nbsp;&lt;\/p&gt;\\r\\n&lt;p&gt;&amp;nbsp;&lt;\/p&gt;\\r\\n&lt;p&gt;&lt;b&gt;References:&lt;\/b&gt;&lt;\/p&gt;\\r\\n&lt;p&gt;1.&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; Croxatto A, Prod'hom G, Greub G. Applications of MALDI-TOF mass spectrometry in clinical diagnostic microbiology.&amp;nbsp;&lt;i&gt;FEMS Microbiol Rev&lt;\/i&gt;. 2012;36(2):380-407. doi:10.1111\/j.1574-6976.2011.00298.x&lt;\/p&gt;\\r\\n&lt;p&gt;2.&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; Alizadeh M, Yousefi L, Pakdel F, et al. MALDI-TOF Mass Spectroscopy Applications in Clinical Microbiology.&amp;nbsp;&lt;i&gt;Adv Pharmacol Pharm Sci&lt;\/i&gt;. 2021;2021:9928238. Published 2021 May 7. doi:10.1155\/2021\/9928238&lt;\/p&gt;\\r\\n&lt;p&gt;3.&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; Pineda FJ, Lin JS, Fenselau C, Demirev PA. Testing the significance of microorganism identification by mass spectrometry and proteome database search.&amp;nbsp;&lt;i&gt;Anal Chem&lt;\/i&gt;. 2000;72(16):3739-3744. doi:10.1021\/ac000130q&lt;\/p&gt;\\r\\n&lt;p&gt;4.&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; Carbonnelle E, Beretti JL, Cottyn S, et al. Rapid identification of Staphylococci isolated in clinical microbiology laboratories by matrix-assisted laser desorption ionization-time of flight mass spectrometry.&amp;nbsp;&lt;i&gt;J Clin Microbiol&lt;\/i&gt;. 2007;45(7):2156-2161. doi:10.1128\/JCM.02405-06.&lt;\/p&gt;\\r\\n&lt;p&gt;5.&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; Alam SI, Kumar B, Kamboj DV. Multiplex detection of protein toxins using MALDI-TOF-TOF tandem mass spectrometry: application in unambiguous toxin detection from bioaerosol.&amp;nbsp;&lt;i&gt;Anal Chem&lt;\/i&gt;. 2012;84(23):10500-10507. doi:10.1021\/ac3028678&lt;\/p&gt;\\r\\n&lt;p&gt;6.&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; Idelevich EA, Sparbier K, Kostrzewa M, Becker K. Rapid detection of antibiotic resistance by MALDI-TOF mass spectrometry using a novel direct-on-target microdroplet growth assay.&amp;nbsp;&lt;i&gt;Clin Microbiol Infect&lt;\/i&gt;. 2018;24(7):738-743. doi:10.1016\/j.cmi.2017.10.016&lt;\/p&gt;\\r\\n&lt;p&gt;7.&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; EU GMP ANNEX 1. Manufacture of Sterile Medicinal. &lt;a href=\\&quot;https:\/\/www.gmp-compliance.org\/guidelines\/gmp-guideline\/eu-gmp-annex-1-manufacture-of-sterile-medicinal-products\\&quot;&gt;https:\/\/www.gmp-compliance.org\/guidelines\/gmp-guideline\/eu-gmp-annex-1-manufacture-of-sterile-medicinal-products&lt;\/a&gt;. Accessed April 27, 2023.&lt;\/p&gt;\\r\\n&lt;p&gt;8.&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; Labandeira-Rey M, Couzon F, Boisset S, et al. Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia.&amp;nbsp;&lt;i&gt;Science&lt;\/i&gt;. 2007;315(5815):1130-1133. doi:10.1126\/science.1137165.&lt;\/p&gt;\\r\\n&lt;p&gt;9.&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp; Bizzini A, Jaton K, Romo D, Bille J, Prod'hom G, Greub G. Matrix-assisted laser desorption ionization-time of flight mass spectrometry as an alternative to 16S rRNA gene sequencing for identification of difficult-to-identify bacterial strains.&amp;nbsp;&lt;i&gt;J Clin Microbiol&lt;\/i&gt;. 2011;49(2):693-696. doi:10.1128\/JCM.01463-10&lt;\/p&gt;\\r\\n&lt;p&gt;10.&amp;nbsp;&amp;nbsp;&amp;nbsp; B\u00f6hme K, Fern\u00e1ndez-No IC, Barros-Vel\u00e1zquez J, Gallardo JM, Ca\u00f1as B, Calo-Mata P. Rapid species identification of seafood spoilage and pathogenic Gram-positive bacteria by MALDI-TOF mass fingerprinting.&amp;nbsp;&lt;i&gt;Electrophoresis&lt;\/i&gt;. 2011;32(21):2951-2965. doi:10.1002\/elps.201100217&lt;\/p&gt;\\r\\n&lt;p&gt;11.&amp;nbsp;&amp;nbsp;&amp;nbsp; Veloo AC, Welling GW, Degener JE. The identification of anaerobic bacteria using MALDI-TOF MS.&amp;nbsp;&lt;i&gt;Anaerobe&lt;\/i&gt;. 2011;17(4):211-212. doi:10.1016\/j.anaerobe.2011.03.026.&lt;\/p&gt;\\r\\n&lt;p&gt;12.&amp;nbsp;&amp;nbsp;&amp;nbsp; Fern\u00e1ndez-Olmos A, Garc\u00eda-Castillo M, Morosini MI, Lamas A, M\u00e1iz L, Cant\u00f3n R. MALDI-TOF MS improves routine identification of non-fermenting Gram negative isolates from cystic fibrosis patients.&amp;nbsp;&lt;i&gt;J Cyst Fibros&lt;\/i&gt;. 2012;11(1):59-62. doi:10.1016\/j.jcf.2011.09.001&lt;\/p&gt;\\r\\n&lt;p&gt;13.&amp;nbsp;&amp;nbsp;&amp;nbsp; Bille E, Dauphin B, Leto J, et al. MALDI-TOF MS Andromas strategy for the routine identification of bacteria, mycobacteria, yeasts, Aspergillus spp. and positive blood cultures.&amp;nbsp;&lt;i&gt;Clin Microbiol Infect&lt;\/i&gt;. 2012;18(11):1117-1125. doi:10.1111\/j.1469-0691.2011.03688.x&lt;\/p&gt;\\r\\n&lt;p&gt;14.&amp;nbsp;&amp;nbsp;&amp;nbsp; Seng P, Drancourt M, Gouriet F, et al. Ongoing revolution in bacteriology: routine identification of bacteria by matrix-assisted laser desorption ionization time-of-flight mass spectrometry.&amp;nbsp;&lt;i&gt;Clin Infect Dis&lt;\/i&gt;. 2009;49(4):543-551. doi:10.1086\/600885.&lt;\/p&gt;\\r\\n&lt;p&gt;15.&amp;nbsp;&amp;nbsp;&amp;nbsp; Kajiwara H, Murakami R. Application of RT-PCR and MALDI-TOF MS for the detection of RNA luteovirus.&amp;nbsp;&lt;i&gt;Anal Biochem&lt;\/i&gt;. 2017;539:45-47. doi:10.1016\/j.ab.2017.10.003.&lt;\/p&gt;\\r\\n&lt;p&gt;16.&amp;nbsp;&amp;nbsp;&amp;nbsp; Khodadadi E, Zeinalzadeh E, Taghizadeh S, et al. Proteomic Applications in Antimicrobial Resistance and Clinical Microbiology Studies.&amp;nbsp;&lt;i&gt;Infect Drug Resist&lt;\/i&gt;. 2020;13:1785-1806. Published 2020 Jun 16. doi:10.2147\/IDR.S238446.&lt;\/p&gt;\\r\\n&quot;}}\">\n<p><a href=\"https:\/\/vospan.com\/san-pham\/vitek-ms-prime-may-dinh-danh-vi-sinh-vat-cong-nghe-khoi-pho-maldi-tof\/\">VITEK <sup>\u00ae<\/sup>\u00a0MS PRIME<\/a> cho ph\u00e9p ph\u00e2n bi\u1ec7t ch\u00ednh x\u00e1c t\u1ea5t c\u1ea3 c\u00e1c lo\u00e0i trong nh\u00f3m\u00a0<i>Bacillus cereus<\/i>\u00a0v\u00e0\u00a0<i>Bacillus subtilis<\/i>\u00a0, v\u1edbi hi\u1ec7u su\u1ea5t dao \u0111\u1ed9ng t\u1eeb 98 \u0111\u1ebfn 100% v\u00e0 x\u00e1c nh\u1eadn m\u1ed1i quan h\u1ec7 ch\u1eb7t ch\u1ebd gi\u1eefa\u00a0<i>Bacillus weihenstephanensis<\/i>\u00a0v\u00e0\u00a0<i>Bacillus mycoides<\/i>\u00a0v\u1edbi kh\u1ea3 n\u0103ng ph\u00e2n bi\u1ec7t t\u01b0\u01a1ng \u0111\u1ed1i th\u1ea5p.<\/p>\n<p><em>Ngu\u1ed3n: <a href=\"https:\/\/www.biomerieux.com\/corp\/en\/resource-hub\/knowledge\/scientific-library\/pharma-microorganisms-library\/mass-spectrometry-maldi-tof-technology-species-level-identificat.html\" target=\"_blank\" rel=\"noopener\">https:\/\/www.biomerieux.com\/corp\/en\/resource-hub\/knowledge\/scientific-library\/pharma-microorganisms-library\/mass-spectrometry-maldi-tof-technology-species-level-identificat.html<\/a><\/em><\/p>\n<p><strong>Minh Khang l\u00e0 nh\u00e0 nh\u1eadp kh\u1ea9u v\u00e0 ph\u00e2n ph\u1ed1i tr\u1ef1c ti\u1ebfp c\u00e1c thi\u1ebft b\u1ecb <a href=\"https:\/\/vospan.com\/product-category\/cong-nghe-sinh-hoc\/thiet-bi-phan-tich-sinh-hoc\/may-dinh-danh-vi-khuan\/\">\u0111\u1ecbnh danh vi khu\u1ea9n<\/a> h\u00e3ng <a href=\"https:\/\/vospan.com\/product-brands\/biomerieux\/\">bioM\u00e9rieux<\/a>.<\/strong><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>C\u00f4ng ngh\u1ec7 kh\u1ed1i ph\u1ed5 MALDI-TOF mang l\u1ea1i h\u1ec7 th\u1ed1ng \u0111\u1ecbnh danh vi sinh v\u1eadt t\u1ef1 \u0111\u1ed9ng v\u1edbi c\u01a1 s\u1edf d\u1eef li\u1ec7u m\u1ea1nh m\u1ebd, gi\u1ea3m th\u1eddi gian ch\u1edd k\u1ebft qu\u1ea3 xu\u1ed1ng c\u00f2n v\u00e0i ph\u00fat, \u0111i\u1ec1u n\u00e0y c\u1ef1c k\u1ef3 c\u00f3 \u00fd ngh\u0129a trong vi\u1ec7c ph\u00e1t hi\u1ec7n v\u00e0 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh tr\u00ean \u0111\u1ed9ng v\u1eadt thu\u1ef7 s\u1ea3n. C\u00f4ng ngh\u1ec7&#8230;<\/p>\n","protected":false},"author":3,"featured_media":9126,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[40],"tags":[],"class_list":["post-9125","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"acf":[],"_links":{"self":[{"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/posts\/9125"}],"collection":[{"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/comments?post=9125"}],"version-history":[{"count":9,"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/posts\/9125\/revisions"}],"predecessor-version":[{"id":11887,"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/posts\/9125\/revisions\/11887"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/media\/9126"}],"wp:attachment":[{"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/media?parent=9125"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/categories?post=9125"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vospan.com\/wp-json\/wp\/v2\/tags?post=9125"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}