MALDI-TOF РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com Thu, 29 Jun 2023 08:51:11 +0000 en-US hourly 1 //wordpress.org/?v=6.1.4 //vospan.com/wp-content/uploads/2021/02/favicon-32x32.png MALDI-TOF РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com 32 32 MALDI-TOF РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com/en/san-pham/maldi-consumables/ Wed, 28 Jun 2023 09:25:57 +0000 //vospan.com/?post_type=product&p=8656

fleXmatrix® delivers high resolution imaging quality while protecting instrument integrity

fleXmatrix® kits enable easy and convenient preparation of matrix solutions for use in MALDI Imaging. Delivered in convenient portion sizes, fleXmatrix® simplifies and speeds up sample preparation. Different kits are available for the MALDI Imaging analysis of lipids, peptides, and proteins, and specialized matrix specifically for MALDI-2 post-ionization analysis.

fleXmatrix® is extra pure to remove potential sources of contamination. This simplifies laboratory workflows and maximizes uptime by removing potential sources of sample or instrument contamination. It comes pre-portioned for ease of preparation and fleXmatrix® dissolves rapidly for short sonication times.

fleXmatrix® is perfectly suited for use with IntelliSlides® and can be used with all of Bruker’s MALDI Imaging platforms. It offers reliable MALDI ionization and is easily removed from tissue samples after MALDI measurement for applications such as histological staining.

Increase productivity

intellislides
IntelliSlides® simplify MALDI Imaging workflows
MALDI Targets

A variety of MALDI targets are available. Proven AnchorChip technology for easiest automation, as well as standard formats available with 96, 384 or 1536 spot geometry.

fleXmatrix
fleXmatrix® �the key to success in MALDI Imaging analyses


IntelliSlides®

Pre-inscribed IntelliSlides® streamline and simplify experimental set up processes in the lab and on all of Bruker’s MALDI Imaging instruments.

IntelliSlides® are a single-use consumable to avoid potential sources of contamination. They fulfill all requirements for reliable MALDI ionization. With all inscriptions on the conductive slide surface, permanent registration marks (teach marks) indicate where to place the sample for alignment within the MALDI instrument.

With a unique serial number and barcode to simplify sample tracking, IntelliSlides® are also compatible with histology and microscopy techniques.

Automated image acquisition is available on Bruker’s timsTOF fleX and rapifleX® platforms with flexImaging 5.1 and above.

 

]]> MALDI-TOF РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com/en/san-pham/rapiflex-maldi-tissuetyper/ Wed, 28 Jun 2023 09:12:21 +0000 //vospan.com/?post_type=product&p=8654

Laser and ion source designed for MALDI tissue typing

During the image acquisition the sample stage moves continually to achieve high pixel rates. The unique smartbeam 3D laser fires at a repetition rate of up to 10 kHz.

The smartbeam 3D laser features a laser diameter of 5 µm, enabling MALDI Imaging of tissue at 20 µm spatial resolution. As illustrated in the video, the laser can move independently from the sample stage to scan the full area of each pixel. This produces truly square pixels which utilizes the total available sample area for maximum sensitivity and pixel-to-pixel reproducibility.

Integrated software solutions

  • flexImaging dedicated molecular histology software controls data acquisition, data visualization, annotation and integration of virtual microscopic slides
  • SCiLSâ„? class= Lab is the dedicated software for statistical analysis. From individual imaging datasets to complete clinical biomarker studies, it features univariate and multivariate methods to mine the data and to find relevant information
Dual rotating mirrors raster the laser beam in an x-y axis which is independent of the x-y motion of the target. The two independent movements combine to create the ideal sampling environment for Imaging: the true, welldefined pixels, as seen above, acquired at maximum acquisition rate.
Smartbeam laser movement
]]> MALDI-TOF РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com/en/san-pham/rapiflex-maldi-pharmapulse/ Wed, 28 Jun 2023 09:00:24 +0000 //vospan.com/?post_type=product&p=8651

rapifleX® MALDI PharmaPulse®

The all new rapifleX® MALDI Time-of-Flight mass spectrometer is the heart of the MALDI PharmaPulse®, it incorporates Brukers latest 10 kHz scanning laser technology and can read multiple samples per second. All components of the system work in concert for fully automatic HTS operation. The newly designed screening software suite supports HTS workflows and works in combination with a proprietary assay development module which empowers assay developer to accelerate label-free assay development for MALDI mass spectrometry. The latest ‚Synthesis Screening�software module of the rapifleX® MPP opens a new application space for e.g. monitoring of chemical reactions at high pace or analysis of binding assays at incomparable high throughput and specificity.

rapifleX® MALDI PharmaPulse® (MPP) combs through large compound libraries of millions of substances

rapifleX MALDI PharmaPulse
Automated Sample Preparation for uHTS �with Courtesy of Analytik Jena

The use of mass spectrometry allows the measurement of unmodified substrates in primary screens to avoid false positives or false negatives, making confirmation screens redundant. The system is designed for fully automatic handling of 384 and 1536 sample plates to screen more than a million compounds in a week in support of drug discovery.

New standard for ultra-High-Throughput Screening Label-Free ‘Hit�Identification

By combining the speed of Bruker’s patented smartbeam 3D laser technology with the direct-detection capability of mass spectrometry, the rapifleX® MPP delivers unprecedented screening capability for ultra high-throughput screening of biochemical and cellular assays. It allows you to screen through large and diverse compound libraries at a pace of over a million compounds a week, epitomizing the perfect balance of automation and miniaturization.

Robustness to analyze 2-3 million samples without intervention

rapifleX MALDI PharmaPulse
CyBio Well vario for uHTS�with Courtesy of Analytik Jena
  • New source and ion optical design
  • No source/ion optic cleaning even within primary screens
  • Easy and fast cleaning if required

Compatible with CyBio®-Well vario with 384 or 1536 channel simultaneous pipettor for high precision and ultra-fast sample plate preparation.

Single digit cost per sample

  • No LC solvents, no waste, no labeling
  • 0.025 to 1 μL sample volume
  • Low cost disposable sample plates

Fully automatic 1536 sample plate change

  • New ultra-fast autoloader seamlessly integrable with common robot systems
  • Rugged design tailored for uHTS operation

New disposable MALDI HTS sample plates

  • Fulfills all requirements for reliable MALDI ionization
  • Suitable for 384, 1536, 3072 or 6144 geometries

 

]]> MALDI-TOF РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com/en/san-pham/rapiflex/ Wed, 28 Jun 2023 07:57:32 +0000 //vospan.com/?post_type=product&p=8648

MALDI-TOF/TOF adds unique capabilities to protein characterization

With speed in mind, we designed the heart of the rapifleX® MALDI Imaging solution to work up to 20 times faster than traditional MALDI-TOF systems, to meet the increasing requirements of tissue imaging or high-throughput primary screening.

The adaptable ion optics and class leading laser technology provide the best data quality, regardless of the acquisition mode or mass range.

The unprecedented 10 kHz speed and ion source robustness, the wide dynamic range, higher specificity and resolution, all contribute to the detailed characterization of biologically and clinically relevant lipids, peptides and proteins, raising customer MALDI-TOF/TOF expectations for applications such as:

  • MALDI Imaging
  • MALDI PharmaPulse high-throughput screening
  • In-depth protein characterization
]]> MALDI-TOF РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com/en/san-pham/microflex-lrf/ Wed, 28 Jun 2023 07:42:13 +0000 //vospan.com/?post_type=product&p=8645

Technology in detail

The microflex® LRF can be operated in positive and negative ion mode using the linear or reflector detector.

The saturation free detector technology enables highest dynamic range and superior performance for high-mass detection.

Ion generation is achieved using a 60 Hz N2-Cartridge-Laser including variable power attenuator and UV optics.

The microScout ion source uses the exact dimensions of 1/4 microtiter plate with a medium area target plate (54 mm x 36 mm), allowing to stay compatible with MTP formats using pipetting robots.

The pumping system is fully integrated into the system and comprises a vacuum measurement and control unit as well as a 70 l/sec turbo-molecular pump and a diaphragm pump.

]]> MALDI-TOF РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com/en/san-pham/autoflex-max-maldi-tof/ Wed, 28 Jun 2023 07:27:18 +0000 //vospan.com/?post_type=product&p=8642
More than 25 years of MALDI – proven technological innovations

The autoflex® maX MALDI systems are built with our proven technological innovations and designed to be a powerful tool for scientists, analytical chemists and researchers around the world.

Featuring the smartbeam-II laser as integral part of MALDI instruments

At the heart of the autoflex® maX is our proprietary smartbeam-II solid state laser. With up to 2 kHz speed in MS mode and 200 Hz for MS/MS, time sensitive analysis �such as would be needed for biopharmaceutical integrity screening �can be made in minutes. The ionization efficiency of the smartbeam-II laser minimizes sample consumption and maximizes quality data output from each target position, even for complex samples. The ionization is gentle enough that tissue samples may be stained after analysis in MALDI MS Imaging workflows. Amenable to a variety of MALDI matrices, the smartbeam-II laser offers a long lifetime for a wide range of applications.

Driven by intuitive softwares, enabling seamless solutions
A key component of the value and walk-up approachability of the autoflex® maX is the Compass software suite, including flexControl for data acquisition and flexAnalysis data analysis. Whether user driven or automated, these softwares support the generation of high quality data quickly and easily. Further, they work in combination with application specific software packages including BioPharma Compass® for biopharmaceuticals, PolyTools for polymers, and SCiLS� class= Lab for MALDI Imaging.

Maintenance made easy
An analytical platform with this range of utility can become a workhorse in the lab, but ion source maintenance is made easy with the push button, IR-laser based self-cleaning of the Perpetual Ion Source. In less than 15 minutes, the autoflex® maX will be ready to resume its workload. Remote service capabilities with Bruker engineers support rapid troubleshooting as well as software and firmware updates on the spot.

autoflex max target
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