Mass Spectrometer РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com Tue, 28 Nov 2023 15:58:41 +0000 en-US hourly 1 //wordpress.org/?v=6.1.4 //vospan.com/wp-content/uploads/2021/02/favicon-32x32.png Mass Spectrometer РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com 32 32 Mass Spectrometer РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com/en/san-pham/plasmaquant-ms-series-icp-ms-tailored-to-your-requirements/ Tue, 28 Nov 2023 07:02:44 +0000 //vospan.com/?post_type=product&p=10303 ICP-MS Tailored to Your Requirements
  • Sensitive â€?1500 Mcps/ppm at <2 % CeO
  • Cost-effective â€?half the argon consumption
  • Fast â€?50 % higher sample throughput
  • Robust â€?matrix-independent long-term stability
  • Versatile â€?optimized for research and routine use
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Mass spectrometry with inductively coupled plasma (ICP-MS) is the versatile, sensitive and fast analytical standard method in various fields of application. With the PlasmaQuant MS series, Analytik Jena offers ICP-MS that exceed all expectations in terms of reliability, precision and throughput and fulfill all requirements for sample handling, robustness and compliance.

Sensitivity and Efficiency

The unparalleled level of sensitivity of the PlasmaQuant MS provides you with analytical advantages that are clearly reflected in efficiency and lower costs per sample. The patented spectrometer design of the ICP-MS systems provide for the lowest detection limits and consistent analytical quality for extremely short integration times and high dilution factors. This ensures high throughput, long-term stability, and reproducible results, while significantly reducing your maintenance costs.

  • Best detection limits
  • High throughput
  • Reduced sample preparation
  • Robust performance
  • Low maintenance requirements

Market Leading Performance and Lowest Running Costs

Analytik Jena’s ICP-MS solutions offer market-leading sensitivity. With these powerful and reliable instruments, laboratories can meet the current challenges of increasing sample throughput or reducing measurement times without sacrificing high analytical precision and reproducibility.

Unmatched detection performance

Excellent mass separation and unmatched detection sensitivity (up to 1500 Mcps/ppm at <2 % CeO) for low abundance isotopes enable the detection of extremely low elemental concentrations, low elemental species concentrations and single particles of less than 5 nm in diameter, as well as offering outstanding precision in the determination of isotope ratios.

Highest sample throughput

In many applications, however, speed of analysis is just as important as detection strength and precision. Higher sample throughput significantly reduces the cost per sample. The unmatched high sensitivity of the PlasmaQuant MS and the resulting precision advantage make it possible to achieve the highest sample throughput in the ICP-MS market with up to 80 samples per hour*.

Powerful plasma flame

The ICP-MS instruments offer excellent plasma robustness, which results in high long-term flame stability. This ensures reliable characterization of samples with high matrix loads as well as minimized drift with changing matrix loads.

Outstanding cost efficiency

The German-made ICP-MS systems are also very economical in daily operation. Compared to other instruments on the market, they consume up to 50 % less argon gas, i.e. approximately 10 l/min. They also achieve a reduction of up to 50â€? in plasma operating costs.The combination of detection strength, speed, reduced argon consumption and high throughput translates into a significantly lower cost per sample. In addition, the design of the system – be it the patented spectrometer or the open book design of the entire instrument, which ensures easy and independent accessibility – reduces maintenance requirements.

]]> Mass Spectrometer РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com/en/san-pham/maldi-consumables/ Wed, 28 Jun 2023 09:25:57 +0000 //vospan.com/?post_type=product&p=8656

fleXmatrix® delivers high resolution imaging quality while protecting instrument integrity

fleXmatrix® kits enable easy and convenient preparation of matrix solutions for use in MALDI Imaging. Delivered in convenient portion sizes, fleXmatrix® simplifies and speeds up sample preparation. Different kits are available for the MALDI Imaging analysis of lipids, peptides, and proteins, and specialized matrix specifically for MALDI-2 post-ionization analysis.

fleXmatrix® is extra pure to remove potential sources of contamination. This simplifies laboratory workflows and maximizes uptime by removing potential sources of sample or instrument contamination. It comes pre-portioned for ease of preparation and fleXmatrix® dissolves rapidly for short sonication times.

fleXmatrix® is perfectly suited for use with IntelliSlides® and can be used with all of Bruker’s MALDI Imaging platforms. It offers reliable MALDI ionization and is easily removed from tissue samples after MALDI measurement for applications such as histological staining.

Increase productivity

intellislides
IntelliSlides® simplify MALDI Imaging workflows
MALDI Targets

A variety of MALDI targets are available. Proven AnchorChip technology for easiest automation, as well as standard formats available with 96, 384 or 1536 spot geometry.

fleXmatrix
fleXmatrix® �the key to success in MALDI Imaging analyses


IntelliSlides®

Pre-inscribed IntelliSlides® streamline and simplify experimental set up processes in the lab and on all of Bruker’s MALDI Imaging instruments.

IntelliSlides® are a single-use consumable to avoid potential sources of contamination. They fulfill all requirements for reliable MALDI ionization. With all inscriptions on the conductive slide surface, permanent registration marks (teach marks) indicate where to place the sample for alignment within the MALDI instrument.

With a unique serial number and barcode to simplify sample tracking, IntelliSlides® are also compatible with histology and microscopy techniques.

Automated image acquisition is available on Bruker’s timsTOF fleX and rapifleX® platforms with flexImaging 5.1 and above.

 

]]> Mass Spectrometer РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com/en/san-pham/rapiflex-maldi-tissuetyper/ Wed, 28 Jun 2023 09:12:21 +0000 //vospan.com/?post_type=product&p=8654

Laser and ion source designed for MALDI tissue typing

During the image acquisition the sample stage moves continually to achieve high pixel rates. The unique smartbeam 3D laser fires at a repetition rate of up to 10 kHz.

The smartbeam 3D laser features a laser diameter of 5 µm, enabling MALDI Imaging of tissue at 20 µm spatial resolution. As illustrated in the video, the laser can move independently from the sample stage to scan the full area of each pixel. This produces truly square pixels which utilizes the total available sample area for maximum sensitivity and pixel-to-pixel reproducibility.

Integrated software solutions

  • flexImaging dedicated molecular histology software controls data acquisition, data visualization, annotation and integration of virtual microscopic slides
  • SCiLSâ„? class= Lab is the dedicated software for statistical analysis. From individual imaging datasets to complete clinical biomarker studies, it features univariate and multivariate methods to mine the data and to find relevant information
Dual rotating mirrors raster the laser beam in an x-y axis which is independent of the x-y motion of the target. The two independent movements combine to create the ideal sampling environment for Imaging: the true, welldefined pixels, as seen above, acquired at maximum acquisition rate.
Smartbeam laser movement
]]> Mass Spectrometer РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com/en/san-pham/rapiflex-maldi-pharmapulse/ Wed, 28 Jun 2023 09:00:24 +0000 //vospan.com/?post_type=product&p=8651

rapifleX® MALDI PharmaPulse®

The all new rapifleX® MALDI Time-of-Flight mass spectrometer is the heart of the MALDI PharmaPulse®, it incorporates Brukers latest 10 kHz scanning laser technology and can read multiple samples per second. All components of the system work in concert for fully automatic HTS operation. The newly designed screening software suite supports HTS workflows and works in combination with a proprietary assay development module which empowers assay developer to accelerate label-free assay development for MALDI mass spectrometry. The latest ‚Synthesis Screening�software module of the rapifleX® MPP opens a new application space for e.g. monitoring of chemical reactions at high pace or analysis of binding assays at incomparable high throughput and specificity.

rapifleX® MALDI PharmaPulse® (MPP) combs through large compound libraries of millions of substances

rapifleX MALDI PharmaPulse
Automated Sample Preparation for uHTS �with Courtesy of Analytik Jena

The use of mass spectrometry allows the measurement of unmodified substrates in primary screens to avoid false positives or false negatives, making confirmation screens redundant. The system is designed for fully automatic handling of 384 and 1536 sample plates to screen more than a million compounds in a week in support of drug discovery.

New standard for ultra-High-Throughput Screening Label-Free ‘Hit�Identification

By combining the speed of Bruker’s patented smartbeam 3D laser technology with the direct-detection capability of mass spectrometry, the rapifleX® MPP delivers unprecedented screening capability for ultra high-throughput screening of biochemical and cellular assays. It allows you to screen through large and diverse compound libraries at a pace of over a million compounds a week, epitomizing the perfect balance of automation and miniaturization.

Robustness to analyze 2-3 million samples without intervention

rapifleX MALDI PharmaPulse
CyBio Well vario for uHTS�with Courtesy of Analytik Jena
  • New source and ion optical design
  • No source/ion optic cleaning even within primary screens
  • Easy and fast cleaning if required

Compatible with CyBio®-Well vario with 384 or 1536 channel simultaneous pipettor for high precision and ultra-fast sample plate preparation.

Single digit cost per sample

  • No LC solvents, no waste, no labeling
  • 0.025 to 1 μL sample volume
  • Low cost disposable sample plates

Fully automatic 1536 sample plate change

  • New ultra-fast autoloader seamlessly integrable with common robot systems
  • Rugged design tailored for uHTS operation

New disposable MALDI HTS sample plates

  • Fulfills all requirements for reliable MALDI ionization
  • Suitable for 384, 1536, 3072 or 6144 geometries

 

]]> Mass Spectrometer РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com/en/san-pham/rapiflex/ Wed, 28 Jun 2023 07:57:32 +0000 //vospan.com/?post_type=product&p=8648

MALDI-TOF/TOF adds unique capabilities to protein characterization

With speed in mind, we designed the heart of the rapifleX® MALDI Imaging solution to work up to 20 times faster than traditional MALDI-TOF systems, to meet the increasing requirements of tissue imaging or high-throughput primary screening.

The adaptable ion optics and class leading laser technology provide the best data quality, regardless of the acquisition mode or mass range.

The unprecedented 10 kHz speed and ion source robustness, the wide dynamic range, higher specificity and resolution, all contribute to the detailed characterization of biologically and clinically relevant lipids, peptides and proteins, raising customer MALDI-TOF/TOF expectations for applications such as:

  • MALDI Imaging
  • MALDI PharmaPulse high-throughput screening
  • In-depth protein characterization
]]> Mass Spectrometer РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com/en/san-pham/microflex-lrf/ Wed, 28 Jun 2023 07:42:13 +0000 //vospan.com/?post_type=product&p=8645

Technology in detail

The microflex® LRF can be operated in positive and negative ion mode using the linear or reflector detector.

The saturation free detector technology enables highest dynamic range and superior performance for high-mass detection.

Ion generation is achieved using a 60 Hz N2-Cartridge-Laser including variable power attenuator and UV optics.

The microScout ion source uses the exact dimensions of 1/4 microtiter plate with a medium area target plate (54 mm x 36 mm), allowing to stay compatible with MTP formats using pipetting robots.

The pumping system is fully integrated into the system and comprises a vacuum measurement and control unit as well as a 70 l/sec turbo-molecular pump and a diaphragm pump.

]]> Mass Spectrometer РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com/en/san-pham/autoflex-max-maldi-tof/ Wed, 28 Jun 2023 07:27:18 +0000 //vospan.com/?post_type=product&p=8642
More than 25 years of MALDI – proven technological innovations

The autoflex® maX MALDI systems are built with our proven technological innovations and designed to be a powerful tool for scientists, analytical chemists and researchers around the world.

Featuring the smartbeam-II laser as integral part of MALDI instruments

At the heart of the autoflex® maX is our proprietary smartbeam-II solid state laser. With up to 2 kHz speed in MS mode and 200 Hz for MS/MS, time sensitive analysis �such as would be needed for biopharmaceutical integrity screening �can be made in minutes. The ionization efficiency of the smartbeam-II laser minimizes sample consumption and maximizes quality data output from each target position, even for complex samples. The ionization is gentle enough that tissue samples may be stained after analysis in MALDI MS Imaging workflows. Amenable to a variety of MALDI matrices, the smartbeam-II laser offers a long lifetime for a wide range of applications.

Driven by intuitive softwares, enabling seamless solutions
A key component of the value and walk-up approachability of the autoflex® maX is the Compass software suite, including flexControl for data acquisition and flexAnalysis data analysis. Whether user driven or automated, these softwares support the generation of high quality data quickly and easily. Further, they work in combination with application specific software packages including BioPharma Compass® for biopharmaceuticals, PolyTools for polymers, and SCiLS� class= Lab for MALDI Imaging.

Maintenance made easy
An analytical platform with this range of utility can become a workhorse in the lab, but ion source maintenance is made easy with the push button, IR-laser based self-cleaning of the Perpetual Ion Source. In less than 15 minutes, the autoflex® maX will be ready to resume its workload. Remote service capabilities with Bruker engineers support rapid troubleshooting as well as software and firmware updates on the spot.

autoflex max target
]]> Mass Spectrometer РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com/en/san-pham/timstof-ultra/ Wed, 28 Jun 2023 07:09:52 +0000 //vospan.com/?post_type=product&p=8639

Unmatched sensitivity with timsTOF Ultra and CaptiveSpray Ultra

Discover the extraordinary capabilities of the timsTOF Ultra mass spectrometer and CaptiveSpray Ultra ion source for groundbreaking omics research. With their combined force, they unleash unparalleled sensitivity, allowing you to conquer samples, detect low-abundance peptides, and make groundbreaking discoveries.

Unlock the hidden secrets: From minute samples to unseen peptides
The timsTOF Ultra and CaptiveSpray Ultra offer a formidable alliance that unlocks hidden secrets in minute samples and unseen peptides. Through the exceptional power of PASEF® acquisition, you can delve into the depths of low-abundance peptides and reveal previously undiscovered information. The incorporation of trapped ion mobility separation eliminates the need for chemical tagging, making the identification of novel peptides effortless. With these advancements, the timsTOF Ultra empowers researchers to redefine what is possible within their labs.

Break boundaries
The timsTOF Ultra transcends conventional limitations, opening doors to new scientific possibilities. Whether it’s single cell proteomics, immunopeptidomics, or plasma proteomics, this instrument delivers unmatched speed and sensitivity. By harnessing the capabilities of the timsTOF Ultra, researchers can push the boundaries of their work and achieve groundbreaking results.

]]> Mass Spectrometer РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com/en/san-pham/timtof-ht/ Wed, 28 Jun 2023 06:53:48 +0000 //vospan.com/?post_type=product&p=8636

TIMS based ion mobility separation and CCS-enabled analysis

The new timsTOF HT mass spectrometer is equipped with the 4th generation high capacity TIMS-XR analyzer and advanced digitizer technology (ADT). It offers higher dynamic range for unmatched analytical depth and quantitation in high-throughput proteomics experiments. The timsTOF HT is fully CCS-enabled and supports all PASEF® acquisition modes including PASEF®, dia-PASEF® and prm-PASEF® achieving flexibility in 4D-Proteomics� class=. Simply uncompromised proteomic depth at scale.

]]> Mass Spectrometer РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com/en/san-pham/timstof-maldi-pharmapulse/ Wed, 28 Jun 2023 04:37:54 +0000 //vospan.com/?post_type=product&p=8633

Unbiased, deep HTS by label-free mass spectrometry

The timsTOF MPP represents the flagship member of the Bruker PharmaPulse® product line. It features the extreme speed and proven robustness of MALDI and, for the first time ever in HTS, takes advantage of Bruker´s innovative Trapped Ion Mobility Spectrometry (TIMS) technology. TIMS enables rapid gas-phase separation of isobars, and even isomers, by exploiting the molecular collisional cross-section. This, in combination with routine 50,000 mass resolution in QTOF-MS detection enables revolutionary levels of assay specificity at HTS speed. timsTOF MPP uses a dual MALDI / ESI ion source with industry-leading 10 kHz smartbeam� class= 3D laser to enable uHTS compatible speed and throughput, and is available with the unique MALDI-2 option for an expanded chemical space.

As part of the solution, the new MALDI PharmaPulse® 2023 software supports a broad range of HTS applications for drug discovery. Its automation interface allows for timsTOF MPP integration in high-throughput environm

Exceptional data quality delivered at uncompromised HTS speed

ents and works in concert with scheduling software from various vendors. Furthermore, MPP 2023 enables seamless transfer of data and results to downstream analysis software, e.g., to Genedata Screener®.

timsTOF MALDI PharmaPulse
]]> Mass Spectrometer РC̫ng ty TNHH TM DV KT Minh Khang //vospan.com/en/san-pham/timstof-scp/ Wed, 28 Jun 2023 04:17:19 +0000 //vospan.com/?post_type=product&p=8630 Redefining single cell proteomics

Advanced ion optics and PASEF to investigate cell heterogeneity and biology from a single cell
Mass spectrometric proteomics has become a staple of modern research in understanding biological function and disease mechanisms. Healthy or diseased tissues that seem homogenous are composed of cells with a variety of different proteomes. The challenge of deciphering the proteomes in each single cell �the cell heterogeneity �holds the key to fully understanding its function.
The timsTOF SCP offers a radically improved ion source concept. Combined with parallel accumulation serial fragmentation (PASEF®) acquisition methods, it provides extremely high speed and sensitivity to tackle proteomes of single cells or post translational modifications in a few cells that are morphologically or functionally similar.

Radically improved ion transfer

The timsTOF SCP features a modified ion source geometry that includes 1 mm capillary identification for five times higher ion transfer into an additional higher pressure stage ion funnel and 8-stage differentially pumped vacuum system.

The larger capillary yields ultra-high sensitivity and the additional orthogonal ion reflection and subsequent funnel offers a separate, differentially pumped stage, maintaining the system robustness expected from the timsTOF instrument series.

Dramatic improvements in proteomics performance

The timsTOF SCP offers improvements in ion transmission into the source while maintaining robustness with an added higher pressure vacuum stage. This results in an almost 5x improvement in ion current. When combined with the Evosep One Whisper method running at 100 nL/min flow rate, and the dia-PASEF method, sensitivity gains of about 100X over previous high-flow results with the Evosep One are achieved. This enables unbiased proteomics at the true single cell level with good reproducibility, robustness and coverage of about 1500 proteins per cell for the first time.

Dual-TIMS, CCS-enabled analysis

Trapped ion mobility spectrometry (TIMS) is first and foremost a separation technique in the gas phase. This resolves sample complexity through an added dimension of separation in addition to high performance liquid chromatography (HPLC) and mass spectrometry, increasing peak capacity and confidence in compound characterization.

Equally important, the TIMS device also accumulates and concentrates ions of a given mass and mobility, enabling a unique increase in sensitivity and speed. A near 100% duty cycle can be achieved with the dual-TIMS technology facilitating accumulation in the front section, while ions in the rear section are sequentially released depending on their mobility. This process of parallel accumulation serial fragmentation (PASEF®) enables collisional cross section (CCS) analysis.

CCS-enabled analysis opens up many further analytical possibilities, from greater certainty of compound identification to confident library matching and lower false discovery rates (FDRs) in large datasets.

Ideal for immunopeptidomics and other enrichment workflows

Besides unbiased true single cell proteomics applications, the timsTOF SCP also offers outstanding sensitivity for workflows that involve enrichment of peptides from the proteome. Immunopeptidomics studies start with purification of immunopeptides from plasma or tissue.

Since immunopeptides are present at relatively low abundance in these samples, the timsTOF SCP is ideal for immunpeptidomics for neo-antigen discovery where the available material is limited, as in needle biopsies. The timsTOF SCP also has the sensitivity to revolutionize the use of phosphoproteomics for the study of signaling pathways in cancer.

PASEF®

Peptide ions are separated using trapped ion mobility spectrometry (TIMS), eluted (~ 100 ms) and detected in the quadropole time of flight (QTOF), generating the TIMS MS heat map. In the PASEF® method the same TIMS separation is used with the quadrupole isolating a certain ion species during its elution and immediately shifting to the next precursor. Parent and fragment spectra are aligned by mobility values.

The parallel accumulation serial fragmentation (PASEF®) technology achieves a sequencing speed of >100 Hz. Using PASEF® increases the MS/MS spectra quality of the low abundant peptides by selecting them several times.

PASEF®: the perfect fit for shotgun proteomics
The timsTOF SCP powered by PASEF® offers a sequencing speed of >100 Hz without losing sensitivity or resolution. This is achieved by synchronizing the quadrupole isolation mass window with the elution time of the specific peptide packages from the TIMS funnel as well as the collision energy in the collision cell.

 

]]> Mass Spectrometer – Công ty TNHH TM DV KT Minh Khang //vospan.com/en/san-pham/timstof-pro-2/ Wed, 28 Jun 2023 04:04:24 +0000 //vospan.com/?post_type=product&p=8627 ®) technology, paves the way for 4D-Multiomics applications. With its proven robustness, high sensitivity and fast MS/MS acquisition, timsTOF Pro 2 is the platform of choice for 4D-Proteomics, 4D-Metabolomics and 4D-Lipidomics.]]> The new standard for high speed, high sensitivity 4D-Multiomics

Liquid chromatography (LC) coupled with mass spectrometry (MS) has become the gold standard in various omics fields. However, the coverage of proteomes or metabolomes in complex biological samples remains challenging due to limited speed, sensitivity and resolution of current mass spectrometers.

Adding trapped ion mobility spectrometry (TIMS) to the equation unlocks the parallel accumulation serial fragmentation (PASEF®) acquisition method to provide extremely high MS/MS speed and sensitivity, requiring minimal sample amounts.

Dual-TIMS and CCS-enabled analysis

TIMS is first and foremost a separation technique in the gas phase. This resolves sample complexity through an added dimension of separation in addition to high performance liquid chromatography (HPLC) and mass spectrometry, increasing peak capacity and confidence in compound characterization.

Equally important, the TIMS device also accumulates and concentrates ions of a given m/z and mobility, enabling a unique increase in sensitivity and speed.

A near 100% duty cycle can be achieved with the dual-TIMS technology facilitating accumulation in the front section, while ions in the rear section are sequentially released depending on their mobility. This process of parallel accumulation serial fragmentation (PASEF®) enables collisional cross section (CCS) analysis.

CCS-enabled analysis opens up many further analytical possibilities, from greater certainty of compound identification to confident library matching and lower false discovery rates (FDRs) in large datasets.

PASEF®

The timsTOF Pro 2 comes with our innovative dual-TIMS analyzer that offers three times higher ion capacity. Simplified ion optics maximize ion transfer and sensitivity to set a new standard in 4D-Multiomics. PASEF® is a redesigned MS/MS technology to meet speed requirements of omics applications. Ions are separated using trapped ion mobility spectrometry, eluted (~ 100 ms) and detected in the quadrupole time of flight (QTOF), generating the TIMS MS heat map. PASEF® then uses the same TIMS separation to serially fragment ions. The quadrupole isolates a certain ion species during its elution for MS/MS and immediately shifts to the next precursor. Parent and fragment spectra are aligned by mobility values. The timsTOF Pro 2 can achieve a sequencing speed of > 120 Hz in PASEF® mode. Furthermore, the MS/MS spectra quality of low abundant analytes can be enriched by selecting them several times.

 

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